The Role of Atrial Structural Remodeling in Atrial Fibrillation Ablation:An Imaging Point of View for Predicting Recurrence

Journal of Atrial Fibrillation
Yasushi AkutsuYouichi Kobayashi

Abstract

Atrial fibrillation (AF) is the most common arrhythmia and is associated with a significant morbidity and mortality. Invasive catheter ablation of AF has emerged as an effective therapy for patients with symptomatic AF. Atrial remodeling, particularly structural remodeling, is important not only for AF persistence but also for AF recurrence after ablation. Atrial dilation and fibrosis are two of the core processes involved in atrial structural remodeling. Increased automaticity and triggered activity occur in atrial structural remodeling, which may cause difficulty in maintaining sinus rhythm after ablation. Furthermore, an enlarged left atrium (LA) may increase the difficulty in achieving catheter stability and thereby require more energy to complete AF ablation. AF causes similar remodeling in both the left and right atria (RA), and myocardial changes in both atria influence AF recurrence. A non-invasive assessment of fibrotic structural remodeling helps predict the outcome of AF ablation. A varie ty of cardiac imaging modalities, such as two- or three-dimensional echocardiography or multi-detector row computed tomography, have been used to estimate the magnitude of atrial structural remodeling by measuring atrial volume or L...Continue Reading

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