The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer

Oncology
Miguel CaballeroJuan J Grau

Abstract

To analyze the role of audiometry in considering change to a less ototoxic treatment in head and neck cancer (HNC) patients. Consecutive patients prescribed high-dose cisplatin (100 mg/m2) between January 2013 and February 2015 were enrolled. Audiometry was performed at baseline and before cisplatin. Change to a less ototoxic agent or reduced cisplatin dose was considered with audiometric decreases >25 dB. A total of 103 patients were included; the median age of the patients was 59 years (range 18-75). Cisplatin was intended curative (58%), adjuvant (32%), or palliative (10%). Forty-two participants (41%) did not commence high-dose cisplatin because of baseline audiometric alterations. Of 61 patients treated with high-dose cisplatin, 40 (66%) showed marked ototoxicity at the end of treatment. The mean hearing loss between initial and final audiometries showed a hearing loss at 4 and 8 kHz in both ears (p = 0.002). Thirteen patients switched to carboplatin and 15 to a lower dose of cisplatin. The outcome was not significantly altered when cisplatin was replaced with carboplatin or cetuximab. Audiometric alterations are common in HNC with high-dose cisplatin, and switching to a less ototoxic regimen does not adversely affect outc...Continue Reading

Citations

Nov 7, 2019·Journal of Pediatric Hematology/oncology·David Rabiço-CostaJorge Spratley
May 22, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Barna BudaiLajos Géczi
Mar 27, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·N M SantucciD Aizenberg
Aug 28, 2021·The Annals of Otology, Rhinology, and Laryngology·Julie HighlandNeil Patel

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