The role of autophagy in endoplasmic reticulum stress-induced pancreatic β cell death

Autophagy
Jia-Jing YinShang-Ha Pan

Abstract

In pancreatic β-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for secretory proteins is localized. Perturbations to ER function of the β-cell, such as those caused by high levels of free fatty acid and insulin resistance, can lead to an imbalance in protein homeostasis and ER stress, which has been recognized as an important mechanism for type 2 diabetes. Macroautophagy (hereafter referred to as autophagy) is activated as a novel signaling pathway in response to ER stress. In this review, we outline the mechanism of ER stress-mediated β-cell death and focus on the role of autophagy in ameliorating ER stress. The development of drugs to take advantage of the potential protective effect of autophagy in ER stress, such as glucagon like peptide-1, will be a promising avenue of investigation.

References

Jan 25, 2003·Cell Calcium·Michael J Berridge
Apr 30, 2003·The Journal of Biological Chemistry·Julie L WebbDavid C Rubinsztein
Apr 8, 2004·Developmental Cell·Beth Levine, Daniel J Klionsky
Apr 13, 2004·Oncogene·Devrim Gozuacik, Adi Kimchi
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Oct 29, 2004·The Journal of Biological Chemistry·Yoshihisa NakataniMunehide Matsuhisa
Dec 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A OakesStanley J Korsmeyer
Mar 11, 2005·The Journal of Biological Chemistry·Dhyan ChandraDean G Tang
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Jan 7, 2006·Cell Death and Differentiation·J Wu, R J Kaufman
Jan 7, 2006·Cell Death and Differentiation·M Boyce, J Yuan
Jan 26, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·Y NakataniM Matsuhisa
Feb 14, 2006·Current Molecular Medicine·Kathryn L LipsonFumihiko Urano
Jun 13, 2006·Trends in Endocrinology and Metabolism : TEM·Blerina KolaMárta Korbonits
Jul 29, 2006·Autophagy·Sara Rodriguez-EnriquezJohn J Lemasters
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Peter ScrivenLynda Wyld
Jan 25, 2007·Molecular Cell·Maria Høyer-HansenMarja Jäättelä
Mar 14, 2007·Autophagy·Sebastián BernalesPeter Walter
Apr 14, 2007·Cell Death and Differentiation·L GalluzziG Kroemer
Nov 28, 2007·Annual Review of Pathology·Jonathan H LinT S Benedict Yen
Dec 1, 2007·Endocrine Reviews·Décio L EizirikMiriam Cnop
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Jun 12, 2008·Diabetes·Woo-Jin SongMehboob A Hussain

❮ Previous
Next ❯

Citations

Mar 26, 2013·Acta Pharmacologica Sinica·Ya-ping YangChun-feng Liu
Oct 16, 2012·The Journal of Clinical Investigation·Alyssa H Hasty, David G Harrison
Dec 19, 2013·International Journal of Endocrinology and Metabolism·Jia Jing YinYang Wang
Jan 5, 2014·Nature Reviews. Microbiology·Ju Huang, John H Brumell
Sep 23, 2014·Trends in Endocrinology and Metabolism : TEM·Myung-Shik Lee
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Shane DeeganAfshin Samali
May 23, 2014·Biochimica Et Biophysica Acta·Lifang YangJian Yang
Sep 25, 2012·Biochemical Pharmacology·Axel H Schönthal
Sep 18, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vanessa J LavallardPhilippe Gual
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi WangShou-Min Xi
Feb 28, 2018·DNA and Cell Biology·Yeong-Min Yoo, Yung Chul Park
Mar 25, 2018·The Journal of Pharmacology and Experimental Therapeutics·Tae Woo JungJi Hoon Jeong
Oct 10, 2013·Endocrinology·Hiroko AbeHirotaka Watada
Feb 19, 2014·International Journal of Molecular Medicine·Xuexin ZhangChao Wang
Jan 1, 2014·Journal of Immunology Research·Susu M ZughaierNael A McCarty
Feb 12, 2017·Clinical Science·Bárbara MaizteguiJuan J Gagliardino
Apr 3, 2021·Molecular Biology Reports·Tapan BehlSwati Chadha
May 1, 2021·International Journal of Molecular Sciences·Jan ŠrámekJan Kovář

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

© 2022 Meta ULC. All rights reserved