The role of autophagy in squamous cell carcinoma of the head and neck

Oral Oncology
Benjamin Cosway, Penny Lovat

Abstract

Half a million new head and neck cancers are diagnosed each year worldwide. Although traditionally thought to be triggered by alcohol and smoking abuse, there is a growing subset of oropharyngeal cancers driven by the oncogenic human papilloma virus (HPV). Despite advances in both surgical and non-surgical treatment strategies, survival rates have remained relatively static emphasising the need for novel therapeutic approaches. Autophagy, the principal catabolic process for the lysosomal--mediated breakdown of cellular products is a hot topic in cancer medicine. Increasing evidence points towards the prognostic significance of autophagy biomarkers in solid tumours as well as strategies through which to harness autophagy modulation to promote tumour cell death. However, the role of autophagy in head and neck cancers is less well defined. In the present review, we summarise the current understanding of autophagy in head and neck cancers, revealing key areas for future translational research.

References

Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·André Lopes CarvalhoLuiz Paulo Kowalski
Jul 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Dec 13, 2005·Nature Reviews. Drug Discovery·Bryan T HennessyGordon B Mills
Feb 9, 2006·PLoS Biology·Gabor Juhasz, Thomas P Neufeld
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Nov 17, 2007·Genes & Development·Noboru Mizushima
May 9, 2009·The Journal of Clinical Investigation·María SalazarGuillermo Velasco
Jun 17, 2009·Cell Host & Microbe·Vojo Deretic, Beth Levine
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Jan 9, 2010·Current Opinion in Cell Biology·Eileen WhiteRobin Mathew
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Oct 6, 2010·The Journal of Cell Biology·Sabrina Di BartolomeoGian Maria Fimia
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Feb 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Hong MaRavi K Amaravadi
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwang-Yu ChangJang-Yang Chang
Nov 15, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rossitza LazovaJohn M Pawelek
May 5, 2012·Archives of Oral Biology·Ji Young KimHae Ryoun Park
Jun 30, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mee Young AhnJung-Hoon Yoon
Jul 10, 2012·American Journal of Otolaryngology·Rong KangShu-Xin Wen
Aug 30, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yan ZangDaniel E Johnson
Jan 5, 2013·Cancer Research·Tomonori KimuraYoshitaka Isaka
Jan 8, 2013·The Journal of Pharmacology and Experimental Therapeutics·Molly L BristolDavid A Gewirtz
Feb 20, 2013·Autophagy·Hana SchmeisserKathryn C Zoon
Feb 22, 2013·International Journal of Molecular Medicine·Yuchen CaiWenqi Jiang
Mar 8, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yawen WangJinsong Hou
Jun 26, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ching-Yu YenYoung-Chau Liu
Oct 3, 2013·PloS One·Takuma InuiHidetoshi Okabe

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Citations

Oct 1, 2016·Oral Oncology·Namrata AdhauliyaRajeshwari G Annigeri
Jul 18, 2017·Marine Drugs·Ming-Fang ChengChing-Feng Weng
Apr 12, 2019·Cells·Fiona H TanCharbel Darido
Jun 14, 2017·EMBO Molecular Medicine·Raquela J ThomasBesim Ogretmen
Nov 20, 2019·Medicinal Research Reviews·Tuhina KhanGiuseppe Campiani
May 28, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xubin YinSonglin Wang
Aug 2, 2017·Scientific Reports·Javier Fernández-MateosRogelio González-Sarmiento
Feb 12, 2017·Virchows Archiv : an International Journal of Pathology·Andresa Borges SoaresVera Cavalcanti de Araújo
Jun 29, 2021·Journal of Photochemistry and Photobiology. B, Biology·Letícia StefenonMarcelo Sperandio

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