The role of B cells in regulating the magnitude of immune response

Microbiology and Immunology
Seiho Nagafuchi

Abstract

Recently, accumulating evidence has suggested that B cell depletion therapy with rituximab is effective not only in autoantibody-associated, but also in T cell-mediated, autoimmune diseases. It is likely that B cells play an important role in regulating the extent of immune response in both physiological and pathological conditions. When a severe infection occurs, pathogens spread throughout the bloodstream. B cells in the blood capture the pathogens, via their specific antigen receptors (surface immunoglobulins), then present the specific antigen to T cells in the spleen, thus increasing the degree of T-cell immune responses to systemic infection. Similarly, in the exacerbation stage of autoimmunity, a large amount of autoantigens may be released into the blood and be captured by autoantigen specific B cells, and this may be followed by presentation of the antigen to CD4 positive autoreactive T cells resulting in extensive activation and proliferation of autoreactive T cells. Thus, it has been suggested that B-cell depletion therapy for autoimmune diseases is most useful for the "vicious cycle" phase of autoreactive immune response. The recognition of this paradigm for the role of B cells in regulating the magnitude of immune ...Continue Reading

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Citations

Dec 25, 2012·Autoimmunity Reviews·Elena GianchecchiAlessandra Fierabracci
Jun 25, 2013·Autoimmunity Reviews·Elena GianchecchiAlessandra Fierabracci
Nov 5, 2013·Autoimmunity Reviews·Elena GianchecchiAlessandra Fierabracci
Nov 30, 2011·International Archives of Allergy and Immunology·Alejandro Vazquez-TelloQutayba Hamid
Mar 26, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Indira HadleyAntoine Sreih
Mar 15, 2018·International Journal of Molecular Sciences·Valeria La MarcaAlessandra Fierabracci

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