Abstract
The bacteriology of cystic fibrosis shows a unique and predictable progression of colonizing micro-organisms. The reason for this sequence is still not known, but thought must be given to the idea that it may be related to the genetic disorder in some way. If this were to be true, an understanding of the colonization mechanisms at all stages in this progression could provide valuable insights for the development of novel therapies. As far as can be ascertained from published studies, mucus is the site of colonization in cystic fibrosis. While there is no doubt that the major pathogen, Pseudomonas aeruginosa, adheres to injured cells more avidly than to intact cells, the overwhelming evidence indicates that it also attaches more avidly to mucus than to intact airway cells by means of specific adhesin-receptor mechanisms. Studies with Staphylococcus aureus, the other major pathogen, are also in progress. These indicate that this organism also has an affinity for mucus. At this time the studies suggest a lesser affinity than P. aeruginosa, at least with adult mucins. These two organisms do not however appear to share the same receptor. In addition to these two major pathogens, Haemophilus influenzae and Streptococcus pneumoniae, p...Continue Reading
References
Dec 14, 1978·Nature·P Kuusela
Jan 1, 1989·Dysphagia·A AguirreM N Hatton
Sep 1, 1989·Infection and Immunity·L SaimanA Prince
Jan 1, 1989·Journal of Comparative Pathology·M C PlotkowskiE Puchelle
Mar 1, 1987·Infection and Immunity·R RamphalG B Pier
Jun 1, 1988·Infection and Immunity·P DoigR T Irvin
May 1, 1985·Infection and Immunity·S Vishwanath, R Ramphal
Sep 1, 1988·Molecular Microbiology·A J van PuttenB Oudega
Jul 1, 1986·The Journal of Infection·P A Friend
Sep 1, 1988·Infection and Immunity·S VishwanathG B Pier
Jul 19, 1985·Science·J D LopesR R Brentani
Mar 1, 1985·Infection and Immunity·H Marcus, N R Baker
Apr 1, 1985·Infection and Immunity·P S CohenD C Laux
Oct 1, 1985·Infection and Immunity·S K OgawaF D Lowy
Jul 1, 1983·Infection and Immunity·R Ramphal, M Pyle
Jan 1, 1983·The American Review of Respiratory Disease·M S NiedermanH Y Reynolds
Jul 1, 1983·Infection and Immunity·R Ramphal, M Pyle
Jul 1, 1984·Infection and Immunity·S Vishwanath, R Ramphal
Jan 1, 1984·Pediatric Pathology·D L SimelP Ingram
Feb 1, 1980·Infection and Immunity·R RamphalP A Small
Apr 1, 1981·Infection and Immunity·V E Davison, B A Sanford
Citations
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·M R VisserJ Verhoef
Aug 1, 1993·The American Review of Respiratory Disease·U E SchwabT F Boat
Jul 3, 1998·American Journal of Respiratory Cell and Molecular Biology·M UlrichG Döring
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·R TirouvanziamE Puchelle
Jan 1, 1990·Infection·M I Marks
Aug 24, 2013·Pediatric Pulmonology·John K WongUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF)
Feb 2, 2015·Auris, Nasus, Larynx·Yong-Jun MaoGao-Yun Xiong
Aug 1, 1993·Respiratory Medicine·G Lamblin, P Roussel
Aug 1, 1993·Journal of Cellular Biochemistry·C J VlahosK S Hirsch
Feb 1, 1992·FEMS Microbiology Reviews·J G Coote
Oct 1, 1994·Archives of Disease in Childhood·G Noble-JamiesonR Y Calne
Jun 12, 2019·American Journal of Respiratory Cell and Molecular Biology·Ashley L CooneyPatrick L Sinn
Jan 1, 1996·Infection and Immunity·J ShuterF D Lowy
Jun 1, 1993·Infection and Immunity·M H McGavinM Höök