PMID: 43503Nov 1, 1979

The role of bacterial enzymes in inducing inflammation in the middle ear cavity

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
S H Lowell, S K Juhn

Abstract

Current knowledge of the pathophysiology of bacterial infections is elementary. Thie initial events leading to the invasion of host tissues are a matter of conjecture for many bacterial organisms. This is particularly true for pneumococci, the most frequent causative organisms of acute otitis media. Bacterial enzymes may account for the initial disruption of host tissues, and this study explored their role in the infectious process. As first step, pneumococcal cultures were analyzed, and significant levels of the enzymes lipase and hyaluronidase were demonstrated. Secondly, the presence of these enzymes in middle ear effusions was explored in an animal model of acute otitis media. The enzymes reached peak levels at seven days. The third and most important portion of the study examined the significance of these enzymes in producing inflammation and alterations in the middle ear cavity of normal experimental animals. This portion was a histologic comparison of temporal bone specimens and demonstrated that marked acute and chronic changes can be induced by placing solutions of these enzymes in the middle ear cavity. This study concludes that bacterial enzymes play an important role in the induction of acute otitis media.

References

Sep 1, 1980·The Annals of Otology, Rhinology, and Laryngology·S H LowellG S Giebink
Oct 2, 2003·The Laryngoscope·Patrick J AntonelliPhilip J Barr
Sep 1, 1989·The Annals of Otology, Rhinology, and Laryngology·C LaurentK Lilja
Apr 5, 2005·The Laryngoscope·Patrick J AntonelliPhilip J Barr

Citations

Mar 8, 1977·Archives of Oto-rhino-laryngology·S K JuhnM M Paparella
Mar 1, 1976·The Annals of Otology, Rhinology, and Laryngology·D J Lim
Jun 1, 1971·The Annals of Otology, Rhinology, and Laryngology·P M Sprinkle, R W Veltri
Jul 30, 1971·American Journal of Ophthalmology·M K Johnson, J H Allen
Oct 1, 1971·Infection and Immunity·C N Shumway, S J Klebanoff
Mar 1, 1974·Lipids·D V Vadehra
Feb 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·J F Whitaker
Aug 1, 1967·The Annals of Otology, Rhinology, and Laryngology·M M Paparella, S Sugiura
Jul 23, 1965·Annals of the New York Academy of Sciences·G T Stewart
May 1, 1971·Journal of Medical Microbiology·T B Dick, C G Gemmell
Jun 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·W M Bonner, E Y Cantey
Jun 12, 1953·Science·S SCHULTZ-HAUDTB G BIBBY
Jul 1, 1970·Infection and Immunity·R Kelly, D Greiff

Related Concepts

Infectious Process
Disorder of Middle Ear
Malignant Neoplasm of Middle Ear
Entire Middle Ear
Enzymes, antithrombotic
Body Cavities
Triacylglycerol Lipase Measurement
Chinchilla<genus>
Dental Caries
Enzymes for Treatment of Wounds and Ulcers

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