PMID: 6179651May 1, 1982

The role of basophils in asthma. I. Sodium cromoglycate on histamine release and content

Clinical Allergy
M K Church

Abstract

The increased plasma-histamine levels observed after provocation of asthmatic subjects with antigen or exercise may result from the release of this granule-associated mediator from either mast cells or basophil leucocytes. In this preliminary study, designed to ilucidate the source and role of mediators in asthma, the effects of sodium cromoglycate on basophil-histamine release has been assessed. Basophil histamine-release in vitro was not inhibited by 0.01-100 microgram/ml sodium cromoglycate. When administered by inhalation at a dose of 20 mg every 8 hr to six subjects, the drug did not modify the ability of basophils to synthesize and store histamine or to release histamine on incubation with antigen. As sodium cromoglycate reduces IgE-dependent histamine release from human mast-cells, these results suggest that lung mast-cells, rather than circulating basophils, are source of mediators in exacerbations of asthma and following exercise or antigen bronchial-provocation in asthmatic subjects.

References

Jun 24, 1978·British Medical Journal·L FerrisD M Temple
Sep 1, 1979·Clinical Allergy·M G HarriesJ Pepys
Dec 1, 1976·The Journal of Allergy and Clinical Immunology·K N BhatE M Tan
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Jan 1, 1973·International Archives of Allergy and Applied Immunology·E S Assem
Jan 1, 1970·International Archives of Allergy and Applied Immunology·E S Assem, J L Mongar
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·S R WalkerJ W Paterson
Jun 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W LorenzM Hutzel
Jan 3, 1981·Lancet·M G HarriesT S Orr
Jul 1, 1980·Clinical Allergy·T S OrrM A Stern
Nov 1, 1980·The American Review of Respiratory Disease·S M Ayres
Mar 1, 1980·The Journal of Clinical Investigation·E C DealE R McFadden
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·G L MartinB Zweiman

Citations

Aug 1, 1987·Agents and Actions·H W GoldenI G Otterness
Jan 1, 1996·International Journal of Immunopharmacology·S KivityE Fireman
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M K ChurchY Okayama
Jan 1, 1984·Annals of the New York Academy of Sciences·S E Lea, S M Dow
Jan 1, 1983·Monographs in Allergy·A B KayB R O'Driscoll
Jun 6, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maarten van den BergeDirkje S Postma
Jan 1, 1987·Experimental Aging Research·S Kemper

Related Concepts

Anti-Immunoglobulin E antibody
Anti-Antibodies
Asthma
Basophils
Vicrom
Dose-Response Relationship, Immunologic
Ceplene
Histamine Release
Immunoglobulin E

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