The role of Bcl-2 family members in non-small cell lung cancer

Seminars in Thoracic and Cardiovascular Surgery
Jonathan C Daniel, W Roy Smythe

Abstract

The treatment of advanced nonsmall cell lung cancer (NSCLC) continues to pose great challenges for the thoracic surgeon. Current therapeutic strategies with chemotherapy and radiation are often ineffective adjuncts to surgery. Accordingly, preclinical research concentration has turned to molecular targets that may prove to be more effective. The Bcl-2 family consists of a homologous network of genes that regulate apoptosis or programmed cell death. Altered expression of members in this family leads to aberrant cell proliferation and malignant growth. This review will discuss the expression and significance of Bcl-2 family members in NSCLC and consider potential methods of intervention that are currently being tested and may have clinical applicability. In addition, the current experience with clinical trials involving Bcl-2 down-regulation in solid organ tumors will be summarized.

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Citations

Dec 13, 2012·Biochimica Et Biophysica Acta·Haidar Akl, Geert Bultynck
Jan 17, 2016·Biochimica Et Biophysica Acta·Mart BittremieuxGeert Bultynck
Oct 29, 2005·Seminars in Thoracic and Cardiovascular Surgery·Eric M Toloza
Feb 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi ZhangPing He
Jul 8, 2014·BioMed Research International·Norahayu Othman, Noor Hasima Nagoor
Jan 15, 2017·Biochimica Et Biophysica Acta. Bioenergetics·Alberto DanesePaolo Pinton
Oct 11, 2014·World Journal of Clinical Oncology·Ian Paul, J Mark Jones
Jan 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weiwei KeZaiming Lu

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