Bile salts (BS) are bio-surfactants present in the gastrointestinal tract (GIT) that play a crucial role in the digestion and absorption of nutrients. The importance of BS for controlled release and transport of lipid soluble nutrients and drugs has recently stimulated scientific interest in these physiological compounds. BS are so-called facial amphiphiles showing a molecular structure that is very distinct from classical surfactants. This peculiar molecular structure facilitates the formation of dynamic aggregates able to solubilise and transport lipid soluble compounds. The detergent nature of BS has been studied in the literature, mostly concentrating on the self-assembly behaviour of BS in solution but also in relation to protein denaturation and its effect on improving proteolysis. In contrast, the affinity of BS for hydrophobic phases has received less attention and studies dealing directly with the interfacial behaviour of BS are very limited in the literature. This is despite the fact that the interfacial activity of BS plays a vital role in fat digestion since it is closely involved with lypolisis. BS adsorb onto fat droplets and can remove other materials such as proteins, emulsifiers and lipolysis products from the ...Continue Reading
Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutions
Bile acid/phosphatidylcholine interactions in mixed monomolecular layers: differences in condensation effects but not interfacial orientation between hydrophobic and hydrophilic bile acid species
The physical properties of glycosyl diacylglycerols. Calorimetric, X-ray diffraction and Fourier transform spectroscopic studies of a homologous series of 1,2-di-O-acyl-3-O-(beta-D-galactopyranosyl)-sn-glycerols
Micellar aggregation and membrane partitioning of bile salts, fatty acids, sodium dodecyl sulfate, and sugar-conjugated fatty acids: correlation with hemolytic potency and implications for drug delivery
Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies
Solubilisation of dipalmitoylphosphatidylcholine bilayers by sodium taurocholate: a model to study the stability of liposomes in the gastrointestinal tract and their mechanism of interaction with a model bile salt
The effect of physiological conditions on the surface structure of proteins: setting the scene for human digestion of emulsions.
Physiological phosphatidylcholine protects bovine beta-lactoglobulin from simulated gastrointestinal proteolysis.
Modulating pancreatic lipase activity with galactolipids: effects of emulsion interfacial composition.
Adsorption of bile salts and pancreatic colipase and lipase onto digalactosyldiacylglycerol and dipalmitoylphosphatidylcholine monolayers
From surfactant adsorption kinetics to asymmetric nanomembrane mechanics: pendant drop experiments with subphase exchange
Effect of gastric conditions on β-lactoglobulin interfacial networks: influence of the oil phase on protein structure
Microscopy, microstructure and displacement of proteins from interfaces: implications for food quality and digestion
Competitive adsorption of dihydroxy and trihydroxy bile salts with whey protein and casein in oil-in-water emulsions
Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals
Micelle dynamic simulation and physicochemical characterization of biorelevant media to reflect gastrointestinal environment in fasted and fed states
Chitosan does not inhibit enzymatic action of human pancreatic lipase in Langmuir monolayers of 1,2-didecanoyl-glycerol (DDG)
Real-time measurements to characterize dynamics of emulsion interface during simulated intestinal digestion
Thermodynamics and Structural Evolution during a Reversible Vesicle-Micelle Transition of a Vitamin-Derived Bolaamphiphile Induced by Sodium Cholate
Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram
Influence of Physiological Gastrointestinal Parameters on the Bioaccessibility of Mercury and Selenium from Swordfish
The role of plant cell wall encapsulation and porosity in regulating lipolysis during the digestion of almond seeds.
Vitamin E and vitamin E acetate solubilization in mixed micelles: physicochemical basis of bioaccessibility
Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts
A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress
Assessment of relative bioavailability of heavy metals in soil using in vivo mouse model and its implication for risk assessment compared with bioaccessibility using in vitro assay
Interactions between cellulose ethers and a bile salt in the control of lipid digestion of lipid-based systems
Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials
Interaction between dietary bioactive peptides of short length and bile salts in submicellar or micellar state
Determination of thermodynamic potentials and the aggregation number for micelles with the mass-action model by isothermal titration calorimetry: A case study on bile salts
Vegetable and fermented vegetable juices containing germinated seeds and sprouts of lentil and cowpea
In vivo digestion of bovine milk fat globules: effect of processing and interfacial structural changes. I. Gastric digestion
Immunoreactivity of hen egg allergens: influence on in vitro gastrointestinal digestion of the presence of other egg white proteins and of egg yolk
Investigations on microstructural changes in pH responsive mixed micelles of Triton X-100 and bile salt
23Na and 35/37Cl as NMR probes of growth and shape of sodium taurodeoxycholate micellar aggregates in the presence of NaCl
In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface
Digestibility and β-carotene release from lipid nanodispersions depend on dispersed phase crystallinity and interfacial properties
Impact of extraneous proteins on the gastrointestinal fate of sunflower seed (Helianthus annuus) oil bodies: a simulated gastrointestinal tract study
AFM in situ DNA
AFM in situ DNA describes in situ analysis (or study) of DNA using atomic force microscopy. Discover the latest research on AFM in situ DNA here.