The role of bilirubin to albumin ratio as a predictor for mortality in critically ill patients without existing liver or biliary tract disease

Acute and Critical Care
Ji Soo ChoiAh Young Leem

Abstract

Hyperbilirubinemia and hypoalbuminemia are frequently appeared and associated with poor prognosis in critically ill patients. We aim to evaluate the association between the bilirubin to albumin ratio and prognosis in intensive care unit (ICU) patients. This was a retrospective study of 731 patients who were admitted to the medical intensive care unit (MICU) at a tertiary-care center from July 2015 to September 2017. We analyzed the bilirubin to albumin ratio on admission to the MICU, including clinical characteristics and other examinations. The overall 28-day survival of MICU patients was 69.1%. On univariate analysis, Acute Physiology and Chronic Health Evaluation (APACHE) II score (P<0.001), Sequential Organ Failure Assessment score (P<0.001), Simplified Acute Physiology Score II score (P<0.001), Creactive protein (P=0.015), and bilirubin/albumin ratio (P<0.001) were associated with mortality of ICU patients. The receiver operating characteristic curves for ICU patients mortality between bilirubin to albumin ratio and APACHE II score were not statistically significant (P=0.282). On multivariate analysis, higher APACHE II score (hazard ratio [HR], 1.05; 95% CI, 1.03 to 1.06; P<0.001) and bilirubin to albumin ratio (HR, 1.65; ...Continue Reading

References

Sep 11, 1996·JAMA : the Journal of the American Medical Association·J R Le GallD Teres
Jul 11, 2001·Critical Care Medicine·J F DhainautC Vinsonneau
Aug 21, 2001·Intensive Care Medicine·M J DuboisY Skrobik
Sep 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophie LanoneJorge Boczkowski
Feb 2, 2006·Intensive Care Medicine·Nicola BrienzaTommaso Fiore
Mar 6, 2007·Critical Care Medicine·Ludwig KramerUNKNOWN Austrian Epidemiologic Study on Intensive Care, ASDI Study Group
May 3, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·C V HulzebosP H Dijk
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Dieter MesottenAlexander Wilmer
Jun 10, 2009·Intensive Care Medicine·Valentin FuhrmannChristian Madl
Oct 1, 2010·European Journal of Gastroenterology & Hepatology·Adam UsluYavuz Coşkun
Jun 8, 2011·Intensive Care Medicine·Valentin FuhrmannPeter Schenk
Jun 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernhard JägerValentin Fuhrmann
Feb 14, 2013·Current Opinion in Critical Care·Thomas HorvatitsValentin Fuhrmann
Feb 15, 2013·Platelets·Avinash R KundurIndu Singh
Oct 22, 2014·Pediatrics·Iman IskanderRichard P Wennberg
Apr 30, 2016·Annals of Translational Medicine·Zhongheng Zhang
Jun 14, 2016·Annals of Translational Medicine·Zhongheng Zhang
Mar 18, 2017·Journal of Critical Care·Charalampos PierrakosUNKNOWN EPIC II investigators
Aug 30, 2017·Chest·Marc JenniskensGreet Van den Berghe

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Citations

Mar 7, 2020·Acute and Critical Care·Jeong Hoon Yang

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