The Role of Biological Skin Substitutes in Stevens-Johnson Syndrome: Systematic Review

Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses
André Oliveira PaggiaroRolf Gemperli

Abstract

Stevens-Johnson syndrome (SJS) is a disease that causes skin exfoliative lesions, characterized by fever, necrosis, and epidermal detachment. Biological skin substitutes may be considered interesting options for the treatment of this disease. This study aims at identifying in the literature the evidence on the current role of these biomaterials in the treatment of SJS and its related diseases. A systematic review with a search period between 2003 and 2017 was carried out, consulting the Lilacs, BVS, and PubMed databases. The quality of the included studies was evaluated by the Oxford Center for Evidence-Based Medicine Classification, for evaluating levels of evidence from the scientific publications. Ninety-five publications were found, and after applying inclusion and exclusion criteria, they resulted in 9 articles. In total, 20 patients with 73.87% average of body surface affected received SJS skin treatment with some biological substitutes, among them are cutaneous allograft, amnion, and xenograft. Mortality rate was 10%, and in these situations, literature indicates mortality rates ranging from 25% to 70%. Effectiveness of the use of biological dressings may be a possible explanation for this finding. Findings indicate the ...Continue Reading

References

Mar 8, 2002·The Journal of Burn Care & Rehabilitation·T L PalmieriF Molitor
Dec 11, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Elisa PianigianiMichele Fimiani
Nov 3, 2006·Burns : Journal of the International Society for Burn Injuries·P PaquetG E Piérard
Aug 1, 2007·Pediatric Transplantation·Johan ArvidsonRolf Gedeborg
Apr 5, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Christine M GresikBrian J Nickoloff
Mar 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Annamma John, John Oommen
Mar 2, 2011·Critical Care Medicine·Roland GerullThomas Schaible
Aug 20, 2011·Burns : Journal of the International Society for Burn Injuries·Andrew J LindfordJyrki Vuola
Jan 27, 2012·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·I O FadeyibiO I Akinola
Feb 25, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·N G FairbairnR W Redmond
May 28, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Christopher AbelaJorge Leon-Villapalos
Mar 30, 2016·The Journal of Surgical Research·Paul WurzerLars P Kamolz
Jun 19, 2016·The British Journal of Dermatology·P Wolkenstein, Y T Wilson
Jun 29, 2016·Burns : Journal of the International Society for Burn Injuries·Jason B YoungSteven A Kahn
Aug 25, 2016·Burns : Journal of the International Society for Burn Injuries·M McCulloughW Garner
Feb 17, 2017·The Journal of Investigative Dermatology·Noel FreyJulia Spoendlin
Oct 17, 2017·Burns : Journal of the International Society for Burn Injuries·M NizamogluP Dziewulski

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Citations

Jun 11, 2020·Advances in Wound Care·Olivia A CharltonAlan Cooper

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