The role of biopsy in diagnosing patients suspected of idiopathic orbital inflammation

Current Eye Research
Ward R BijlsmaRachel Kalmann

Abstract

To provide a framework when to biopsy patients suspected of idiopathic orbital inflammation (IOI). One-hundred seventeen patients were selected with signs of orbital inflammation in whom after history and physical examination, no definite diagnosis was made. In this cohort, the role of biopsy in making a diagnosis was evaluated and compared to a therapeutic trial of corticosteroids. In 67 of 117 patients, a diagnosis was evident after imaging and laboratory testing. In 50 remaining patients, a decision had to be made to biopsy or administer a therapeutic trial of corticosteroids. Thirty-nine patients underwent biopsy as the next step. Nine patients underwent a therapeutic trial of corticosteroids of which one was subsequently subjected to biopsy. Two patients spontaneously resolved. No patients with a malignancy were inadvertently treated with corticosteroids. One patient experienced a biopsy related complication but did not lose vision. This study suggests using a therapeutic trial of corticosteroids only in patients with low suspicion of malignancy with muscular and apical mass localizations, or with optic-nerve compression. This framework was demonstrated to be safe in not delaying diagnosis of malignancies and efficient in ...Continue Reading

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Citations

Dec 3, 2014·Journal français d'ophtalmologie·F MouriauxN Martin-Silva
May 21, 2013·Journal français d'ophtalmologie·E HalimiP Labalette
Aug 21, 2013·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Imtiaz A ChaudhryAlberto Galvez
Jun 22, 2017·International Ophthalmology·Puneet S BraichTimothy J McCulley
Oct 16, 2019·The Journal of International Medical Research·Xin Su, Liqing Zhang
Jul 28, 2020·Progress in Retinal and Eye Research·Min Joung LeeJames T Rosenbaum

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