PMID: 22563665May 9, 2012Paper

The role of bioreactors in cartilage tissue engineering

Current Stem Cell Research & Therapy
Nigel MabvuureWasim S Khan

Abstract

Cartilage tissue engineering is concerned with developing in vitro cartilage implants that closely match the properties of native cartilage, for eventual implantation to replace damaged cartilage. The three components to cartilage tissue engineering are cell source, such as in vitro expanded autologous chondrocytes or mesenchymal progenitor cells, a scaffold onto which the cells are seeded and a bioreactor which attempts to recreate the in vivo physicochemical conditions in which cartilage develops. Although much progress has been made towards the goal of developing clinically useful cartilage constructs, current constructs have inferior physicochemical properties than native cartilage. One of the reasons for this is the neglect of mechanical forces in cartilage culture. Bioreactors have been defined as devices in which biological or biochemical processes can be re-enacted under controlled conditions e.g. pH, temperature, nutrient supply, O2 tension and waste removal. The purpose of this review is to detail the role of bioreactors in the engineering of cartilage, including a discussion of bioreactor designs, current state of the art and future perspectives.

Citations

Feb 6, 2016·ACS Applied Materials & Interfaces·Rosalyn D AbbottDavid L Kaplan
Mar 18, 2015·Advanced Drug Delivery Reviews·Sonia Font TelladoMartijn Van Griensven
Dec 1, 2012·Biotechnology Progress·Jillian M BrennerStephen D Waldman
Oct 7, 2014·Macromolecular Bioscience·Nandana BhardwajBiman B Mandal
Dec 23, 2014·Organogenesis·Maria Giovanna Francipane, Eric Lagasse
Sep 10, 2014·Journal of Biomedical Materials Research. Part a·Li YuJohn P Fisher
Apr 7, 2015·Methods : a Companion to Methods in Enzymology·Rosalyn D AbbottDavid L Kaplan
May 6, 2015·Trends in Biotechnology·Rosalyn D Abbott, David L Kaplan
Apr 20, 2016·Stem Cell Research & Therapy·Jonathan C Bernhard, Gordana Vunjak-Novakovic
Mar 1, 2018·Journal of Tissue Engineering and Regenerative Medicine·Nopporn SawatjuiTravis Klein
Apr 25, 2018·Biotechnology and Bioengineering·Nida TanataweethumAbhinav Bhushan
May 8, 2018·Advanced Healthcare Materials·Jesus Paez-MayorgaAli Khademhosseini
Dec 19, 2012·The Open Orthopaedics Journal·Giacomo RizzelloVincenzo Denaro
May 4, 2017·Tissue Engineering. Part B, Reviews·Ke LiXizheng Zhang
Aug 4, 2020·Science Advances·Vladislav A ParfenovVladimir A Mironov
Feb 6, 2018·Journal of Tissue Engineering·Andrew C DalyDaniel J Kelly
Jan 16, 2020·Materials·Haowen KwanWasim S Khan
Aug 24, 2021·Emerging Topics in Life Sciences·Charlotte H HulmeSally Roberts
Oct 24, 2021·Journal of Tissue Engineering and Regenerative Medicine·Eva Goldberg-BockhornNicole Rotter

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