The role of birth weight on the causal pathway to child and adolescent ADHD symptomatology: a population-based twin differences longitudinal design.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Kai Xiang LimJean-Baptiste Pingault

Abstract

Available evidence points towards lower birth weight as a risk factor for the development of attention deficit/hyperactivity disorder (ADHD) symptoms. We probed the causal nature of this putative effect of birth weight on ADHD symptoms using the twin differences design, which accounts for genetic and shared environmental confounds. In a large population-based twin sample - 3,499 monozygotic (MZ) and 6,698 dizygotic (DZ) pairs - parents, teachers or twins rated the twins' ADHD symptoms at nine assessment waves (2-16 years). We implemented the twin differences design, which completely accounts for shared environmental and genetic confounding in MZ twins. We tested whether: (a) the lighter-born twins had elevated ADHD symptoms compared to the heavier-born twins, by regressing within-pair differences of ADHD symptoms on within-pair differences of birth weight among MZ twins; (b) the effect of birth weight on ADHD was moderated by gender, gestational age and low birth weight; (c) this effect changed with age at ADHD assessment using adapted latent growth curve models; and (d) results differed for inattention and hyperactivity/impulsivity. Birth weight significantly predicted ADHD symptoms from early childhood to late adolescence. Th...Continue Reading

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Citations

Mar 7, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jeffrey M Craig
Sep 22, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Andrea G AllegriniRobert Plomin
Nov 3, 2020·Neuropharmacology·Annika L WeißMarieke Klein
Feb 16, 2021·The British Journal of Psychiatry : the Journal of Mental Science·Massimiliano OrriMarie-Claude Geoffroy
Dec 30, 2020·Scientific Reports·Pei-Yin Pan, Sven Bölte
Sep 10, 2020·Cold Spring Harbor Perspectives in Medicine·Tom A McAdamsJean-Baptiste Pingault

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