The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis

Expert Review of Clinical Immunology
Jan Lycke, Henrik Zetterberg

Abstract

Multiple sclerosis (MS) is an immune-mediated chronic neurodegenerative disease of the central nervous system (CNS). Therapeutic interventions with immunomodulatory agents reduce disease activity and disability development, which are monitored clinically and by magnetic resonance imaging (MRI). However, these measures largely lack information on the impact from these therapies on inflammation, demyelination and axonal injury, the essential pathophysiological features of MS. Several biomarkers for inflammation and neurodegeneration have been detected in cerebrospinal fluid (CSF). In MS, some of these biomarkers seem to reflect disease activity, disability progression, and therapeutic response. Areas covered: In this review, we describe the most promising CSF biomarkers of inflammation and degeneration for monitoring therapeutic interventions in MS. We also describe the evolution of highly sensitive immunoassays that enable determination of neuron-specific biomarkers in blood. Expert commentary: Together with clinical and MRI measures, CSF biomarkers may improve the assessment of therapeutic efficacy and make personalized treatment possible. One disadvantage has been the need of repetitive lumbar punctures to obtain CSF. However,...Continue Reading

References

Sep 1, 1993·The Journal of Cell Biology·M K LeeD W Cleveland
Nov 1, 1995·Journal of the Neurological Sciences·L E RosengrenO Andersen
Jan 1, 1996·Annual Review of Neuroscience·M K Lee, D W Cleveland
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Apr 4, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J N LyckeL E Rosengren
Nov 4, 2000·Neurochemical Research·L F EngY L Lee
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Jan LyckeLars Ståhle
Aug 28, 2003·Lancet Neurology·Geert LycklamaFrederik Barkhof
Sep 23, 2003·Brain Research·Niklas NorgrenTorgny Stigbrand
Jan 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A PetzoldG Giovannoni
May 18, 2005·Journal of the Neurological Sciences·Axel Petzold
Jan 18, 2006·Brain : a Journal of Neurology·Christian Confavreux, Sandra Vukusic
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanUNKNOWN AFFIRM Investigators
Mar 3, 2006·The New England Journal of Medicine·Richard A RudickUNKNOWN SENTINEL Investigators
Sep 25, 2007·Clinical Chemistry·John ToddPhilippe Goix
May 14, 2008·Archives of Neurology·Manjit BraitchCris S Constantinescu
Jun 10, 2008·Journal of Neuroimmunology·Francesca AloisiBarbara Serafini
Oct 4, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Carlo Pozzilli, Luca Prosperini
Feb 4, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N PutzkiV Limmroth
Feb 18, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KhademiT Olsson
Dec 17, 2009·Multiple Sclerosis : Clinical and Laboratory Research·J MellergårdC Dahle
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Jonatan SalzerPeter Sundström
Jan 22, 2010·The New England Journal of Medicine·Ludwig KapposUNKNOWN FREEDOMS Study Group
Mar 20, 2010·Brain : a Journal of Neurology·Manuel ComabellaXavier Montalban
Jun 11, 2010·Brain : a Journal of Neurology·Antonio ScalfariGeorge C Ebers
Jun 15, 2010·Journal of Neuroinflammation·Dafna Bonneh-BarkayClayton A Wiley
Jul 6, 2010·Neurobiology of Disease·Violaine K HarrisSaud A Sadiq
Oct 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Lars BörnsenFinn Sellebjerg
Dec 8, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Mohsen KhademiTomas Olsson
Dec 17, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Jorge Correale, Marcela Fiol
Feb 1, 2011·Annals of Neurology·Martin GunnarssonJan Lycke
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky

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Citations

Apr 18, 2020·Neurology·Oluf Andersen, Massimo Filippi
Apr 30, 2019·Frontiers in Immunology·Florian DeisenhammerUwe K Zettl
Mar 6, 2019·Therapeutic Advances in Neurological Disorders·Yinan ZhangOlaf Stüve
Jun 30, 2019·Journal of Neuroinflammation·Massimiliano CastellazziPaolo Pinton
May 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jesse HuangIngrid Kockum
Aug 31, 2020·Multiple Sclerosis and Related Disorders·L NovakovaJ Lycke
Apr 24, 2021·Frontiers in Neuroscience·Carolina Ferreira-AtuestaSharmilee Gnanapavan
Aug 17, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Igal RosensteinJan Lycke

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