The role of bone morphogenetic proteins 2, 4, 6 and 7 during ovarian follicular development in sheep: contrast to rat

Reproduction : the Official Journal of the Society for the Study of Fertility
Jennifer L JuengelKenneth P McNatty

Abstract

The intraovarian roles of BMP family members such as BMP2, 4, 6 and 7 are not well understood, particularly in species with low ovulation rates such as sheep. Therefore, the objectives of these experiments were to determine the expression patterns of mRNAs encoding BMP2, 4, 6 and 7 during ovarian follicular development in sheep, and to determine the effects of these growth factors on ovine granulosa cell functions in vitro. For comparative purposes, the effects of these BMPs were also determined in rat granulosa cells since these factors have been most widely studied in this poly-ovulatory species. As assessed by in situ hybridization, non-atretic ovine follicles expressed mRNA for BMP6 but not 2, 4 or 7. Furthermore, expression of BMP6 was limited to the oocyte of primordial as well as primary, pre-antral and antral follicles. Reverse transcription-PCR of granulosa cell mRNA detected low levels of all the BMPs in some pools of cells. BMP2, 4, 6 and 7 each inhibited progesterone production from ovine granulosa cells without affecting cellular proliferation/survival. Similarly, these BMPs inhibited progesterone production from rat granulosa cells. However, they also stimulated cellular proliferation/survival of the rat granulosa...Continue Reading

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Citations

Sep 21, 2011·Archives of Gynecology and Obstetrics·Farfaras AthanasiosKassanos Demetrios
Nov 13, 2010·Molecular and Cellular Biochemistry·Hiromichi YamashitaTakashi Shimizu
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Sep 13, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Jia Yi LinKenneth P McNatty
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Apr 11, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Francois ParadisGeorge R Foxcroft
Jun 27, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Jennifer L JuengelKenneth P McNatty
Apr 9, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Janet L CrawfordKenneth P McNatty
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