The role of bradykinin receptor type 2 in spontaneous extravasation in mice skin: implications for non-allergic angio-oedema

British Journal of Pharmacology
Marion BishaTatsiana Suvorava

Abstract

Non-allergic angio-oedema is a life-threatening disease mediated by activation of bradykinin type 2 receptors (B2 receptors). The aim of this study was to investigate whether activation of B2 receptors by endogenous bradykinin contributes to physiological extravasation. This may shed new light on the assumption that treatment with an angiotensin converting enzyme inhibitor (ACEi) results in an alteration in the vascular barrier function predisposing to non-allergic angio-oedema. We generated a new transgenic mouse model characterized by endothelium-specific overexpression of the B2 receptor (B2tg ) and established a non-invasive two-photon laser microscopy approach to measure the kinetics of spontaneous extravasation in vivo. The B2tg mice showed normal morphology and litter size as compared with their transgene-negative littermates (B2n ). Overexpression of B2 receptors was functional in conductance vessels and resistance vessels as evidenced by B2 receptor-mediated aortic dilation to bradykinin in presence of non-specific COX inhibitor diclofenac and by significant hypotension in B2tg respectively. Measurement of dermal extravasation by Miles assay showed that bradykinin induced extravasation was significantly increased in B2...Continue Reading

References

Dec 8, 1977·Nature·T J Williams, M J Peck
Oct 1, 1992·The Annals of Pharmacotherapy·J L Ulmer, M J Garvey
Jun 1, 1972·The Anatomical Record·M Takada, S Hattori
Apr 1, 1993·Internal Medicine·Y OikeY Numata
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·E G SheselyO Smithies
Sep 3, 1998·The Journal of Biological Chemistry·H JuR C Venema
Sep 12, 1998·Lancet·J NussbergerA Agostoni
Oct 16, 1999·Nature·B FisslthalerR Busse
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·J NussbergerA Agostoni
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Aug 23, 2002·The New England Journal of Medicine·Juerg NussbergerMarco Cicardi
Oct 1, 1964·The Journal of Cell Biology·E R WEIBEL, G E PALADE
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferUNKNOWN Valsartan in Acute Myocardial Infarction Trial Investigators
Oct 12, 2005·Circulation·Tatsiana SuvoravaGeorg Kojda
Dec 24, 2005·Physiological Reviews·Dolly Mehta, Asrar B Malik
Apr 10, 2007·Lancet·Roland E SchmiederBernhard M W Schmidt
Apr 28, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S A FelipeS I Shimuta
Jul 11, 2007·Allergy·M BasG Kojda
Feb 23, 2008·Angiogenesis·Janice A NagyHarold F Dvorak
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
Sep 30, 2009·British Journal of Pharmacology·Marie-Thérèse BawolakFrançois Marceau
May 13, 2010·Deutsche medizinische Wochenschrift·Murat BasG Kojda
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Sep 8, 2010·The New England Journal of Medicine·Marco CicardiWing-Tze Fan
Jun 5, 2013·Scientific Reports·Gyohei EgawaKenji Kabashima
Aug 14, 2013·PloS One·Andrew V BenestHellmut G Augustin
Jun 14, 2014·British Journal of Pharmacology·K OmoriT Murata
Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Jan 30, 2015·The New England Journal of Medicine·Murat BaşThomas K Hoffmann
May 13, 2015·British Journal of Pharmacology·John C McGrath, Elliot Lilley

❮ Previous
Next ❯

Citations

Mar 30, 2020·Tissue Engineering. Part B, Reviews·Greet MerckxAnnelies Bronckaers
Mar 3, 2020·Thérapie·Marion LepelleyLaurence Bouillet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
I Del CorsoP Migliorini
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
L BouilletAnne Gompel
© 2022 Meta ULC. All rights reserved