The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut

European Journal of Pain : EJP
Jing YangYanqing Li

Abstract

Previous studies suggested that brain-derived neurotrophic factor (BDNF) might act as an important modulator in chronic pain states. However, no systematic study has used knock-out mice to clarify its effect on visceral sensitivity. In the present study, 2,4,6-trinitrobenzene sulfonic acid (TNBS) was administered to heterozygous (BDNF(+/-)) knock-out and wild-type (BDNF(+/+)) mice to induce colitis. Visceral response to colorectal distension (CRD) and bladder reactivity were recorded. Results demonstrated that in normal state, BDNF(+/-) and BDNF(+/+) mice did not differ in the visceral response to CRD at <60 mm Hg pressure and the bladder reactivity; however, with 60 mm Hg pressure, BDNF(+/-) mice showed a weaker visceral response to CRD. In inflammatory state of colitis, TNBS induced upregulation of BDNF in dorsal root ganglia of both genotypes while BDNF(+/-) mice showing significantly lower sensitivity in the colon at 30 mm Hg and lower sensitivity in bladder than BDNF(+/+) mice. The two genotypes showed no significant difference in inflammatory severity. Thus, BDNF deficiency results in developmental changes in colonic nociception in both control and inflammatory states, which are more significant in inflammatory state. For...Continue Reading

Associated Clinical Trials

Jan 16, 2015·Craig A. Friesen, MD

References

Jun 19, 1998·Neuroreport·D OddiahM Rattray
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·X Q Shu, L M Mendell
Jun 28, 2000·The Clinical Journal of Pain·S C Apfel
Aug 10, 2000·Gastroenterology·M ReinshagenG Adler
May 1, 2002·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Haim Ben-AmiAlexandra Lavy
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·David E ElliottJoel V Weinstock
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth H KampG F Gebhart
Feb 26, 2003·Annals of Neurology·Martin KerschensteinerReinhard Hohlfeld
Mar 23, 2004·Behavioural Brain Research·Geneviève-Anne Gaudreau, Victor Plourde
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D QuarcooA Braun
Oct 1, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenneth LambKlaus Bielefeldt
Mar 7, 2006·Neuroscience Research·Koichi Obata, Koichi Noguchi
Apr 21, 2006·Autonomic Neuroscience : Basic & Clinical·Valentina VasinaRoberto De Giorgio
May 19, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R HohlfeldH Wekerle
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R M de PablosA Machado
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L A BlackshawM Schemann
May 19, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E S KimballP J Hornby
Oct 9, 2007·Neuroscience·A P Malykhina
Oct 20, 2007·The Journal of Physiology·Sarah J SpencerQuentin J Pittman
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N Vergnolle
May 24, 2008·Novartis Foundation Symposium·Michael Spedding, Pierre Gressens
Aug 7, 2008·Genes, Brain, and Behavior·A J Saylor, J F McGinty

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Citations

Jan 9, 2014·Rheumatology International·Adriano Prado SimãoAna Cristina Rodrigues Lacerda
Jan 16, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F JardíP Vergara
Feb 14, 2012·Neuroscience Letters·Rachel D MoloneyJohn F Cryan
Oct 2, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D H VasantS Hamdy
Aug 31, 2016·Journal of Gastroenterology and Hepatology·Qingqing QiXiuli Zuo
Feb 23, 2018·European Journal of Clinical Investigation·Daphne MargoniEleftheria Roma
Jun 18, 2019·Current Neuropharmacology·Ana CoelhoCélia Duarte Cruz
Sep 28, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Sumei Liu
Nov 2, 2014·Biological Research for Nursing·Elizabeth D E PapathanassoglouMaria N Karanikola
Mar 15, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Beverley Greenwood-Van MeerveldAnthony C Johnson
Mar 16, 2018·Behavioural Pharmacology·Ana E López-PérezRaquel Abalo
Feb 2, 2021·Frontiers in Psychiatry·Thomas Jan KonturekMiriam Goebel-Stengel
Apr 22, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Chen-Li SunJia-Xiang Ni

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