PMID: 3474967Jan 1, 1987Paper

The role of brain peptides in neuroimmunomodulation

Annals of the New York Academy of Sciences
S M McCannC Aguila

Abstract

Since neuroimmunomodulation is brought about in part, at least, by secretion of pituitary hormones involved in stress and immune responses, we review briefly the hypothalamic control of the release of ACTH, growth hormone, and prolactin. The release of ACTH is controlled particularly by corticotropin-releasing factor (CRF), but vasopressin has intrinsic releasing activity and potentiates the action of CRF at both hypothalamic and pituitary levels. Oxytocin may even potentiate the action of CRF, but has little, if any, ACTH-releasing activity by itself. In addition, epinephrine may augment responses to the CRFs. In contrast, growth hormone is under dual control by growth-hormone-releasing factor (GRF) and somatostatin, and prolactin is under multifactorial control by a series of inhibitors and stimulators. Dopamine is accepted as a physiological prolactin-inhibiting factor (PIF), but probably GABA and possibly acetylcholine as well are PIFs. There is good evidence for a peptide PIF as well. There are a number of prolactin-releasing factors (PRFs) which include oxytocin, vasoactive intestinal polypeptide, PHI and TRH. Several other peptides can also release prolactin, including angiotensin II. In response to stress there is a com...Continue Reading

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Citations

May 1, 1989·Immunology Letters·B D Janković
Jan 1, 1989·Psychoneuroendocrinology·D Saphier
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L MilenkovicS M McCann
Oct 7, 2010·Journal of Endocrinological Investigation·T F KrzeminskiB Kos-Kudła
Nov 1, 1991·The International Journal of Neuroscience·A I Awerbuch, R Sandyk
Dec 12, 2002·Chest·Tarja Saaresranta, Olli Polo
Feb 1, 1990·Journal of Endodontics·M R ByersC L Kimberly
Apr 6, 2019·Medicinal Research Reviews·Emilio Gil-MartínAlejandro Romero
Dec 31, 2002·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Wladimir GoreckiElie Belorizky

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