The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease.

Frontiers in Endocrinology
Hong-Jin ChenCheng-Chao Ruan

Abstract

Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases.

References

Jul 1, 1976·Clinics in Endocrinology and Metabolism·J Hirsch, B Batchelor
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Aug 1, 1989·The American Journal of Physiology·N J Rothwell, M J Stock
Dec 1, 1985·Annals of Internal Medicine·E L Barrett-Connor
Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·P HuttunenV Kinnula
Jan 1, 1983·Clinical Science·N J Rothwell, M J Stock
Sep 1, 1981·Circulation·O de DivitiisM Mancini
Aug 16, 2000·American Journal of Physiology. Cell Physiology·J Himms-HagenS Cinti
Nov 27, 2002·Circulation·Yoshihisa OkamotoYuji Matsuzawa
Feb 8, 2003·Science·Enzo NisoliMichele O Carruba
Jan 1, 1964·The American Journal of Physiology·R E SMITH, J C ROBERTS
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
May 11, 2004·Genes & Development·Frédéric RelaixMargaret Buckingham
Jul 28, 2004·Physiology & Behavior·A M J van OoijenK R Westerterp
Nov 3, 2004·Circulation·Robert H EckelUNKNOWN American Heart Association
Apr 22, 2005·Nature·Frédéric RelaixMargaret Buckingham
Jun 9, 2005·American Journal of Physiology. Endocrinology and Metabolism·James G GrannemanYuyan Lu
Dec 15, 2006·Nature·Evan D Rosen, Bruce M Spiegelman
Jul 10, 2007·Cell Metabolism·Patrick SealeBruce M Spiegelman
Aug 23, 2008·Nature·Patrick SealeBruce M Spiegelman
Dec 9, 2008·Journal of Molecular and Cellular Cardiology·Smita SihagJohn J Lehman
Apr 10, 2009·The New England Journal of Medicine·Wouter D van Marken LichtenbeltG J Jaap Teule
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Apr 10, 2009·The New England Journal of Medicine·Kirsi A VirtanenPirjo Nuutila
Jul 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Sara B PoliceLisa A Cassis
Jul 20, 2010·Genesis : the Journal of Genetics and Development·Christoph Lepper, Chen-Ming Fan
Jun 2, 2011·Journal of Aging Research·Tina Wenz
Dec 12, 2012·The Journal of Clinical Investigation·Kristin I StanfordLaurie J Goodyear
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Shiqin XiongR Wayne Alexander
Mar 19, 2013·Journal of the American College of Cardiology·Paolo Raggi
Jun 19, 2013·Nature Communications·A PlanavilaF Villarroya
Sep 3, 2013·Nature Reviews. Immunology·Kathryn J MooreEdward A Fisher
Mar 11, 2015·Nature Communications·Jimmy F P BerbéePatrick C N Rensen

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