The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation.

The Journal of Biological Chemistry
Y R ChenT H Tan

Abstract

c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environmental stresses, and apoptotic agents. The mechanisms by which JNK integrates with other signaling pathways and regulates the diverse cellular events are unclear. We found JNK, but not p38-mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase 2, to be persistently activated in apoptosis induced by gamma radiation, UV-C, and anti-Fas treatment. Direct correlation was found between JNK activation and apoptosis induced by UV-C and gamma radiation; however, JNK induction and apoptosis induced by Fas signaling were not well correlated. Overexpression of activated JNK1 caused cell death in transfected cells, and the expression of a dominant-negative mutant of MAPK kinase 1 or JNK1 (but not a dominant-negative mutant of p38-MAPK or c-Raf) prevented the UV-C- and gamma radiation-induced cell death. The inductions of JNK in T-cell activation and apoptosis were distinguished by the different activation patterns, transient versus persistent, respectively. Co-treatment with a tyrosine phosphatase inhibitor (sodium orthovanadate) and T-cell activation signals (phorbol 12-myristate 13-acetate plus ionomycin) prolonged JNK...Continue Reading

References

Apr 1, 1992·Current Opinion in Cell Biology·E Rozengurt
May 1, 1992·Molecular Biology of the Cell·L E Heasley, G L Johnson
Jul 30, 1992·Nature·J M KyriakisJ Avruch
Nov 24, 1995·Science·Z XiaM E Greenberg
Mar 10, 1995·Science·S Nagata, P Golstein
Sep 29, 1995·The Journal of Biological Chemistry·J K WestwickD A Brenner
Jul 14, 1995·The Journal of Biological Chemistry·M Karin
Dec 1, 1994·Immunology Today·G NúñezM González-García
Mar 10, 1995·Science·H Steller
Mar 13, 1995·Journal of Immunological Methods·S A MemonC M Zacharchuk
Dec 1, 1994·Molecular and Cellular Biology·H K SlussR J Davis
Sep 2, 1994·Science·C A Lange-Carter, G L Johnson
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Dec 22, 1995·The Journal of Biological Chemistry·N SakataE W Gelfand
Jan 12, 1996·The Journal of Biological Chemistry·Y R ChenT H Tan

❮ Previous
Next ❯

Citations

Oct 16, 2013·Journal of Dermatological Science·Ji-Seon LeeHyuk-Jin Cha
Apr 13, 2000·International Journal of Cancer. Journal International Du Cancer·J KleeffM Korc
May 8, 2001·International Journal of Cancer. Journal International Du Cancer·I V FilippovichJ F Chatal
Feb 22, 2002·Journal of Biochemical and Molecular Toxicology·Joshua A Bomser
Jun 16, 2001·Journal of Cellular Biochemistry·F BernassolaG Melino
Feb 10, 2000·Archives of Biochemistry and Biophysics·Y H KimE Niki
Feb 1, 2000·Biochemical and Biophysical Research Communications·C H WooJ H Kim
May 18, 2000·Biochemical and Biophysical Research Communications·Y H KimE Niki
Dec 14, 2001·Biochemical and Biophysical Research Communications·K KomatsuzakiI Nishimoto
Jan 1, 2002·Environmental Health and Preventive Medicine·Masato Matsuoka, Hideki Igisu
Jul 18, 2001·Pathology Oncology Research : POR·I Peták, J A Houghton
Apr 2, 2013·Archives of Toxicology·Krishnendu SinhaParames C Sil
Jan 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Michel H BourguignonEdgardo D Carosella
Sep 17, 2009·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·V K PuduvalliA P Kyritsis
Dec 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·J H WangB Y Chen
Apr 14, 2007·Apoptosis : an International Journal on Programmed Cell Death·Tadashi AsakuraKiyoshi Ohkawa
Jan 19, 2012·Apoptosis : an International Journal on Programmed Cell Death·Nabendu BiswasSantu Bandyopadhyay
Nov 21, 2013·Apoptosis : an International Journal on Programmed Cell Death·Mitul N BavariaLeonard R Johnson
Apr 24, 2009·Archives of Pharmacal Research·Lian Yu GuoYeong Shik Kim
Sep 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·M S I AbazaA M Kollamparambil
Mar 27, 2007·Journal of the American Society for Mass Spectrometry·Randall J BatemanKevin E Yarasheski
Feb 21, 2004·Journal of Photochemistry and Photobiology. B, Biology·Gautam Sethi, Ajit Sodhi
Mar 19, 2004·Life Sciences·Annayya R Aroor, Shivendra D Shukla
Dec 4, 2003·Mutation Research·Helotonio CarvalhoCarlos Frederico Martins Menck
Aug 7, 2002·The American Journal of Pathology·Samir Kumar-SinghChristine Van Broeckhoven
Jun 27, 2002·Biochemical and Biophysical Research Communications·Neeta SinghSameena Azmi
Sep 6, 2002·Biochemical Pharmacology·Edward D Owuor, Ah-Ng Tony Kong

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis