The role of C5a in hypersensitivity reactions in the lung

Pulmonary Pharmacology
J F Regal


What role the complement system in general, and C5a in particular play in hypersensitivity reactions in the lung is unknown. A review of the available studies indicates that C5a can mimic hypersensitivity reactions in the lung by virtue of its ability to cause cell infiltration and edema in the lung, cause a short lived airway hyperreactivity and cause bronchoconstriction. Its ability to cause contraction of isolated airways and in vivo bronchoconstriction in the guinea-pig is due to the release of histamine and arachidonate metabolites, mediator systems similar to those evoked by antigen-antibody reactions in the guinea-pig lung. To begin to determine if C5a generation with complement system activation was an important contributor to antigen-induced bronchoconstriction, the response to antigen was assessed in animals depleted of complement by cobra venom factor and unresponsive to C5a. Unexpectedly, these animals responded to antigen with a much greater bronchoconstriction than did animals with an intact complement system. This suggested that an intact complement system was somehow important in limiting allergic bronchoconstriction or conversely that allergic bronchoconstriction might be heightened when preceded by complement ...Continue Reading


Jan 1, 1978·Advances in Immunology·T E Hugli, H J Müller-Eberhard
Jan 1, 1978·Clinical Allergy·B J Hutchcroft, A Guz
Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Oct 12, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·C GrossklausW Vogt
Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·B Damerau, W Vogt
May 1, 1975·Journal of Applied Physiology·J M Drazen, K F Austen
Jan 1, 1988·International Archives of Allergy and Applied Immunology·H JürgensenW Schmutzler
Apr 1, 1985·The Journal of Experimental Medicine·Z MaromM Kaliner
Jan 1, 1988·International Archives of Allergy and Applied Immunology·J F Regal
Jul 1, 1988·The Journal of Clinical Investigation·R R Kew, R O Webster
Jan 1, 1986·Complement·T E Hugli
Jan 1, 1986·Complement·E L Morgan
Jan 1, 1987·Clinical and Experimental Pharmacology & Physiology·C L ArmourN Berend
Jan 1, 1987·International Archives of Allergy and Applied Immunology·J F Regal, R L Bell
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W MandeckiJ L Fox
Mar 1, 1971·The Journal of Experimental Medicine·A B KayK F Austen
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Jan 1, 1967·International Archives of Allergy and Applied Immunology·G Bodammer, W Vogt
Aug 1, 1967·The Journal of Experimental Medicine·P A Ward
Jan 1, 1983·International Archives of Allergy and Applied Immunology·J F RegalL W Chakrin
Mar 1, 1983·Prostaglandins·R Hamel, A W Ford-Hutchinson
Jul 13, 1984·European Journal of Pharmacology·B R CreeseW M Bothwell
Nov 1, 1983·The Journal of Allergy and Clinical Immunology·W W PleskowJ G Curd
Jan 1, 1983·International Journal of Immunopharmacology·J F Regal, R J Pickering
Jun 1, 1981·The Journal of Experimental Medicine·R C WigginsP M Henson
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Gerard, T E Hugli
May 7, 1982·European Journal of Pharmacology·A PrancanB B Vargaftig
Mar 1, 1980·Clinical Immunology and Immunopathology·D E ChenowethT E Hugli

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Dec 1, 1994·European Journal of Cancer Care·R D MacleodM Charny

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