The role of Ca(2+) activated Cl(-) channels in blood pressure control

Current Opinion in Pharmacology
Vladimir MatchkovChristian Aalkjaer

Abstract

Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.

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Citations

Jan 6, 2016·The Journal of Physiology·Silvia Cruz-RangelJorge Arreola
Nov 20, 2016·The Journal of Physiology·Silvia Cruz-RangelJorge Arreola
Jan 26, 2017·Journal of Cellular Physiology·Mohammad Amin Kamaleddin
Feb 14, 2018·Basic & Clinical Pharmacology & Toxicology·Anders Bisgaard JensenVladimir V Matchkov
Feb 28, 2018·British Journal of Pharmacology·Nils J G RorsmanPaolo Tammaro
Feb 3, 2018·Cardiovascular Research·Rhian M TouyzAugusto C Montezano
Jan 14, 2021·Scientific Reports·Michele CelestinoCarla Mucignat-Caretta
Feb 23, 2021·Pulmonary Circulation·Guogu LiuAiguo Dai

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