The role of Ca2+ in muscle cell damage

Annals of the New York Academy of Sciences
Hanne Gissel

Abstract

Skeletal muscle is the largest single organ of the body. Skeletal muscle damage may lead to loss of muscle function, and widespread muscle damage may have serious systemic implications due to leakage of intracellular constituents to the circulation. Ca2+ acts as a second messenger in all muscle and may activate a whole range of processes ranging from activation of contraction to degradation of the muscle cell. It is therefore of vital importance for the muscle cell to control [Ca2+] in the cytoplasm ([Ca2+]c). If the permeability of the sarcolemma for Ca2+ is increased, the muscle cell may suffer Ca2+ overload, defined as an inability to control [Ca2+]c. This could lead to the activation of calpains, resulting in proteolysis of cellular constituents, activation of phospholipase A2 (PLA2), affecting membrane integrity, an increased production of reactive oxygen species (ROS), causing lipid peroxidation, and possibly mitochondrial Ca2+ overload, all of which may further worsen the damage in a self-reinforcing process. An increased influx of Ca2+ leading to Ca2+ overload in muscle may occur in a range of situations such as exercise, mechanical and electrical trauma, prolonged ischemia, Duchenne muscular dystrophy, and cachexia. Co...Continue Reading

References

Apr 1, 1992·International Journal of Sports Medicine·J A DuarteH J Appell
Jul 1, 1991·Physiological Reviews·T ClausenM E Everts
May 1, 1990·The American Journal of Physiology·T E Gunter, D R Pfeiffer
Nov 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E P ThyssenD M Spiegel
Feb 1, 1990·Medicine and Science in Sports and Exercise·L E ArmstrongR W Hubbard
Jan 29, 1986·Biochimica Et Biophysica Acta·C HidalgoA M García
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Mar 1, 1984·Clinical Science·D A JonesR H Edwards
Oct 1, 1984·European Journal of Clinical Investigation·M J JacksonR H Edwards
May 1, 1995·Neuromuscular Disorders : NMD·M LindahlE P Hoffman
Sep 1, 1993·The American Journal of Physiology·J BhattacharyyaM M Sayeed
Aug 1, 1993·European Journal of Biochemistry·U G FöhrC W Heizmann
Apr 1, 1993·Acta Physiologica Scandinavica·M E EvertsT Clausen
May 1, 1993·The Journal of Membrane Biology·P R TurnerR A Steinhardt
Mar 1, 1993·Journal of Applied Physiology·A N Belcastro
Dec 1, 1995·Cell Calcium·G R Monteith, B D Roufogalis
Jun 1, 1996·The Journal of Physiology·M W Fryer, D G Stephenson
Oct 11, 1996·The American Journal of Physiology·F W HopfR A Steinhardt
Feb 1, 1996·Journal of Applied Physiology·B B RubinR J Korthuis
Apr 7, 1997·The Journal of Cell Biology·P L McNeil, R A Steinhardt
Jun 6, 1998·Molecular and Cellular Biochemistry·A N BelcastroD A Raj
May 12, 1998·The American Journal of Physiology·C D Balnave, D G Allen
May 13, 1998·Acta Physiologica Scandinavica·J D BrutonH Westerblad
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A B WilliamsP O Hasselgren
Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·G D ArthurA N Belcastro
Dec 11, 1999·Muscle & Nerve·M A Badalamente, A Stracher
Jan 22, 2000·Cell Calcium·R RizzutoT Pozzan
Jun 8, 2000·Annals of the New York Academy of Sciences·R C LeeC T Chen
Jul 25, 2000·Journal of Applied Physiology·D NetheryG Supinski
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H Gissel, T Clausen
Sep 16, 2000·Biochemical Society Symposium·M CromptonJ M Ward
Jan 5, 2001·Annals of Surgery·P O Hasselgren, J E Fischer
Feb 24, 2001·American Journal of Physiology. Cell Physiology·K R SultanD Pette
Jun 20, 2001·Acta Physiologica Scandinavica·J Fridén, R L Lieber
Oct 16, 2001·Journal of Agricultural and Food Chemistry·I H LambertN Ørtenblad
Apr 19, 2002·Journal of Applied Physiology·Kristian OvergaardTorben Clausen
Sep 18, 2002·The Journal of Cell Biology·Clarisse VandebrouckPhilippe Gailly
Nov 2, 2002·The Journal of Physiology·Louise J BeatonStuart M Phillips
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hanne Gissel, Torben Clausen

❮ Previous
Next ❯

Citations

Aug 2, 2013·Current Pain and Headache Reports·Luciana UemotoMarco Antonio Cavalcanti Garcia
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lama Al-QusairiAnna Buj-Bello
Aug 12, 2008·Human Molecular Genetics·Michael P WalkerA Gregory Matera
Aug 30, 2012·The Journal of Pharmacology and Experimental Therapeutics·Marco Brotto, Eduardo L Abreu
Jun 18, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Emma CockburnGlyn Howatson
May 23, 2008·American Journal of Physiology. Cell Physiology·Rainer NgJohn A Faulkner
Jun 6, 2009·American Journal of Physiology. Cell Physiology·Gregory N FilatovMark M Rich
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ira J SmithPer-Olof Hasselgren
Nov 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Atta U ShahbazKarl T Weber
Mar 31, 2009·American Journal of Respiratory Cell and Molecular Biology·Gerald S Supinski, Leigh Ann Callahan
Feb 5, 2008·The Journal of Clinical Investigation·Andrew M BellingerAndrew R Marks
Feb 3, 2011·The Journal of Clinical Investigation·Sanjeewa A GoonasekeraJeffery D Molkentin
Aug 27, 2013·Antioxidants & Redox Signaling·Christopher W WardW Jonathan Lederer
Jan 10, 2012·Lasers in Medical Science·Mariana Zingari CamargoSolange de Paula Ramos
Jan 13, 2015·International Scholarly Research Notices·M Saleet Jafri
Dec 18, 2013·Seminars in Pediatric Neurology·Christos D KatsetosJoseph J Melvin
Jun 26, 2012·Forensic Science International : Synergy·Arpad A Vass
Jul 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M FarellaS Palla
Jun 10, 2009·The Journal of Surgical Research·Ligia M ContrinJean Louis Vincent
Sep 22, 2007·Anesthesiology Clinics·Ansgar M Brambrink, Jeffrey R Kirsch
Mar 16, 2011·Muscle & Nerve·Chad D MarkertRobert W Grange
Mar 19, 2014·Head & Neck·Marion E CouchHirak Der-Torossian
Oct 1, 2013·Free Radical Biology & Medicine·Wataru AoiToshikazu Yoshikawa
Dec 3, 2014·Medical Hypotheses·Michael BehringerKazunori Ken Nosaka
Jan 19, 2016·The Journal of Physiology·Tanya R CullyBradley S Launikonis
Dec 3, 2014·PloS One·Francesca LangoneGianni Cesareni
Mar 27, 2016·Journal of Neurochemistry·Balaraju SunithaMuchukunte Mukunda Srinivas Bharath
Jan 20, 2007·Developmental Biology·Liquan CaiDonald D Brown
Oct 25, 2016·Mitochondrion·Madhusudanarao Vuda, Ashwin Kamath
Nov 6, 2014·Medicine and Science in Sports and Exercise·Alexandre FouréJulien Gondin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.