The role of cancer-associated autoantibodies as biomarkers in paraneoplastic myositis syndrome

Current Opinion in Rheumatology
Xin LuGuochun Wang

Abstract

The aim of this study is to provide a comprehensive overview of the current insight about the clinical utility of cancer-associated autoantibodies (CAAs) as biomarkers in paraneoplastic myositis syndrome (PMS). In addition, the possible mechanisms of the relationship between malignancy and myositis onset are discussed. It has become increasingly clear that a subgroup of the myositis-specific autoantibodies could be considered as CAAs because they are closely related to the PMS. Increased risk of cancer was found in patients with antitranscriptional intermediary factor 1-γ (TIF1-γ), antinuclear matrix protein-2 (NXP-2), anti3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) or antismall ubiquitin-like modifier 1-activating enzyme (SAE) antibodies. However, the diagnosing sensitivity and specificity of these CAAs for PMS are different among different cohort studies. Abnormally expressed or mutated autoantigen genes in tumor could possibly induce cross immunity against self-proteins and subsequently lead to the development of PMS. Anti-TIF1-γ, anti-NXP-2, anti-HMGCR and anti-SAE antibodies may act as CAAs in PMS. It is necessary to closely screen and monitor for cancer in patients with CAAs. The recent studies of the relation...Continue Reading

References

Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Nov 1, 2006·Arthritis and Rheumatism·Ira N TargoffUNKNOWN International Myositis Collaborative Study Group
Mar 30, 2007·Annals of the Rheumatic Diseases·Hector ChinoyRobert G Cooper
Sep 29, 2011·Arthritis and Rheumatism·Ernesto Trallero-AraguásMiquel Vilardell-Tarrés
Feb 28, 2015·American Journal of Clinical Dermatology·Jeannette M OlazagastiFloranne C Ernste
Oct 3, 2015·Clinical Reviews in Allergy & Immunology·Eleni Tiniakou, Andrew L Mammen
Apr 19, 2016·Brain : a Journal of Neurology·Yves AllenbachOlivier Benveniste
Aug 19, 2016·Journal of Cutaneous Medicine and Surgery·Judy K QiangRaed Alhusayen
Oct 21, 2016·Neurology. Neuroimmunology and Neuroinflammation·Masato KadoyaJun Shimizu
Nov 18, 2017·Rheumatology·Iago Pinal-FernandezAlbert Selva-O'Callaghan
Sep 21, 2018·Current Opinion in Rheumatology·Anna Ghirardello, Andrea Doria

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Citations

Apr 23, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuancang JiangMarilyn Diaz
May 8, 2021·Expert Review of Neurotherapeutics·Franz Blaes
Aug 8, 2021·Journal of Neuropathology and Experimental Neurology·Alan Pestronk, Rati Choksi

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