The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

Cancers
Francesco BonolloSofia Karkampouna

Abstract

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and progression, since stromal elements are required to generate the optimal conditions for cancer cell proliferation, invasion, and possibly metastasis. Prostate cancer (PCa), though easily curable during primary stages, represents a clinical challenge in advanced stages because of the acquisition of resistance to anti-cancer treatments, especially androgen-deprivation therapies (ADT), which possibly lead to uncurable metastases such as those affecting the bone. An increasing number of studies is giving evidence that prostate TME components, especially cancer-associated fibroblasts (CAFs), which are the most abundant cell type, play a causal role in PCa since the very early disease stages, influencing therapy resistance and metastatic progression. This is highlighted by the prognostic value of the analysis of stromal markers, which may predict disease recurrence and metastasis. However, further investigations on the molecular mechanisms of tumor-stroma interactions are still needed to develop novel therapeutic approaches targeting stromal components. In this review, we report the current knowledge of the characteristics and functions of the str...Continue Reading

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Citations

Dec 31, 2020·Biomedicines·Avan KaderMarcus R Makowski
Feb 5, 2021·Journal of Xenobiotics·Natalie SilkDianzheng Zhang
Apr 7, 2021·Prostate Cancer and Prostatic Diseases·Jacob Stultz, Lawrence Fong
May 6, 2021·International Journal of Molecular Sciences·Vicenç Ruiz de PorrasAlbert Font
Jun 15, 2021·ACS Biomaterials Science & Engineering·Jeehun ParkJunsang Doh
Jul 14, 2021·The Prostate·Bruno D A SanchesSebastião R Taboga

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Methods Mentioned

BETA
exome
xenografts
xenograft
chip
nuclear translocation
immunoprecipitation

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