The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress

American Journal of Physiology. Heart and Circulatory Physiology
Manabu ShibasakiFumihiro Tajima

Abstract

The mechanism(s) for the changes in cardiac function during heat stress remain unknown. This study tested two unique hypotheses. First, sympathetic innervation to the heart is required for increases in cardiac systolic function during heat stress. This was accomplished by comparing responses during heat stress between paraplegics versus tetraplegics, with tetraplegics having reduced/absent cardiac sympathetic innervation. Second, stimulation of skin thermoreceptors contributes to cardiovascular adjustments that occur during heat stress in humans. This was accomplished by comparing responses during leg only heating between paraplegic versus able-bodied individuals. Nine healthy able-bodied, nine paraplegics, and eight tetraplegics participated in this study. Lower body (i.e., nonsensed area for para/tetraplegics) was heated until esophageal temperature had increased by ~1.0°C. Echocardiographic indexes of diastolic and systolic function were performed before and at the end of heat stress. The heat stress increased cardiac output in all groups, but the magnitude of this increase was attenuated in the tetraplegics relative to the able-bodied (1.3 ± 0.4 vs. 2.3 ± 1.0 l/min; P < 0.05). Diastolic function was maintained in all groups...Continue Reading

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Citations

Jan 3, 2016·Autonomic Neuroscience : Basic & Clinical·Zachary J SchladerCraig G Crandall
Sep 29, 2018·Heart·Alexandra Mackenzie WilliamsChristopher Roy West
Oct 20, 2017·European Journal of Preventive Cardiology·Earric LeeJari A Laukkanen
Nov 1, 2018·Temperature : Multidisciplinary Biomedical Journal·Anthony S LeichtGlen P Kenny
Jun 27, 2019·Temperature : Multidisciplinary Biomedical Journal·Michelle B TrbovichMike J Price
Aug 15, 2015·Journal of Applied Physiology·Jody L GreaneyW Larry Kenney
Feb 4, 2021·Biomedical Engineering Online·Weiyan RenYubo Fan
Sep 11, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Philippe GendronDaniel Gagnon

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