PMID: 8950304Jan 1, 1996Paper

The role of catecholamines in cocaine toxicity: a model for cocaine "sudden death"

Life Sciences
B MetsD W Landry

Abstract

Sudden death associated with cocaine abuse is preceded by a state of agitated delirium. We postulated that release of catecholamines associated with this stress enhanced toxicity from cocaine. Thus we investigated the effect of catecholamine infusion [(epinephrine (7.25 ugml-1), norepinephrine (4.4 ugml-1) and dopamine (8.0 ugml-1), infused at 6 ml h-1] on the toxicity from concomitant infusion of cocaine (1 mg-kg-1 min-1). Two groups of rats were studied in order to isolate distinct toxicity endpoints: convulsions and respiratory arrest in conscious, and, circulatory arrest in anesthetized and ventilated rats. Catecholamines were administered at either full or 1/2 strength to establish a dose response effect on cocaine toxicity. Catecholamine infusion in a dose dependent fashion provoked earlier convulsions and respiratory arrest in conscious rats and circulatory arrest in anesthetized and ventilated rats. Despite lower cocaine cumulative dose administration, rats receiving catecholamines had similar plasma cocaine concentrations at the onset of convulsions and respiratory arrest compared to those with cocaine infusion alone. The data suggest that catecholamines enhance the convulsive, respiratory and circulatory toxicity of c...Continue Reading

References

Dec 4, 1986·The New England Journal of Medicine·L L Cregler, H Mark
Apr 1, 1986·Journal of Pharmacokinetics and Biopharmaceutics·K S PangL Endrenyi
Jan 1, 1985·Acta Obstetricia Et Gynecologica Scandinavica·T LundebergV Lundström
Jul 25, 2009·Alimentary Pharmacology & Therapeutics·C GajperiaG Lyratzopoulos

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Citations

Mar 7, 2003·European Journal of Pharmacology·John B WilliamsMark M Knuepfer
Oct 16, 2002·Journal of Immunological Methods·Shi Xian DengDonald W Landry
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·B MetsD W Landry
Oct 11, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Philippe GoninPierre-Nicolas Carron
May 8, 2001·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·K S ParkS O Henderson

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