The role of catecholamines in memory impairment in chicks following reduced gas exchange in ovo

Neuroscience
E J CammM E Gibbs

Abstract

We have shown previously that reducing gas exchange to chick embryos by half wrapping eggs with an impermeable membrane from either days 14-18 (W14-18) or days 10-18 (W10-18) of the 21 day incubation results in post-hatch memory deficits. In the W10-18 chicks, short-term memory following training is impaired, whereas in the W14-18 chicks, memory is intact for 30 min but does not consolidate into long-term storage. The reduction in gas exchange caused by half wrapping eggs resulted in alterations in hematocrit, O2 and CO2 tensions suggesting that the embryos are hypoxic and hypercapnic. Our aim was to test the hypothesis that increases in circulating levels of catecholamines in ovo, as a result of hypoxia, lead to a disturbance of the central noradrenergic pathways resulting in cognitive impairment. Noradrenaline is critical for memory consolidation and a disturbance during development could compromise cognitive ability. In the present study, plasma noradrenaline levels were significantly elevated compared with control levels 2 days after hatch in W14-18 chicks. There was also a decrease in tissue noradrenaline concentration in the anterior forebrain in both W14-18 and W10-18 chicks. The differential ability of centrally adminis...Continue Reading

References

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Apr 5, 2001·Brain Research. Developmental Brain Research·G W DentS Levine
Sep 7, 2001·Neuropharmacology·R RevillaA Fernández-López
Dec 18, 2001·Brain Research. Developmental Brain Research·E J CammR Harding
Sep 18, 2002·Progress in Neurobiology·Marie E Gibbs, Roger J Summers
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew DerrickSidhartha Tan
Feb 6, 2004·Brain Research. Developmental Brain Research·Candice L RodricksMarie E Gibbs

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Citations

Apr 2, 2011·High Altitude Medicine & Biology·Carlos E SalinasDino A Giussani
Nov 26, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marie E GibbsSuzanne L Miller
Oct 2, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Candice L RodricksSuzanne L Miller
Jul 18, 2008·Neurobiology of Aging·Marie E GibbsDavid H Small
Sep 13, 2005·Brain Research. Developmental Brain Research·Emily J CammSandra M Rees
Oct 19, 2006·Brain Research·Candice L RodricksMarie E Gibbs
Mar 4, 2008·The Journal of Experimental Biology·Sheva KhorramiWarren Burggren

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