PMID: 6414255Jan 1, 1983Paper

The role of catecholamines in the regulation of gonadotropin secretion

Acta Morphologica Hungarica
C A Barraclough

Abstract

Earlier neuropharmacological evidence suggested a role for the central catecholamine (CA) system in the regulation of gonadotropin secretion. To resolve whether dopamine (DA) or norepinephrine (NE) was the important CA involved in evoking the preovulatory release of LHRH and to evaluate the temporal sequence of changes in the CAs which occur prior to and during preovulatory-like gonadotropin surges, we evaluated turnover rates (T/R) of DA and NE in micro-dissected regions of the hypothalamus of proestrous rats. We also examined whether similar changes in T/R occur in ovariectomized (OVX), estrogen-(E2)-treated rats and how progesterone (P) amplifies and advances the time of the LH surge in this rat model system. In these studies we used a radioenzymatic assay to measure CA content and alpha-MPT to block CA synthesis and provide information on the rate of CA efflux. This information was used to calculate T/R. In proestrous rats, a dramatic increase in NE T/R occurred prior to and during the LH surge whereas DA T/R initially increased and then markedly declined during the afternoon of proestrus. The NE T/R changes occurred in the medial preoptic nucleus (MPN), suprachiasmatic nucleus (SCN), arcuate nucleus (AN) and median eminenc...Continue Reading

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