The role of CCL21 in recruitment of T-precursor cells to fetal thymi.

Blood
Cunlan LiuY Takahama

Abstract

During embryonic development, T-lymphoid precursor cells colonize the thymus. Chemoattraction by the fetal thymus is thought to mediate T-precursor cell colonization. However, the molecules that attract T-precursor cells to the thymus remain unclear. By devising time-lapse visualization in culture, the present results show that alymphoid fetal thymus lobes attract T-precursor cells from fetal liver or fetal blood. CD4(-)CD8(-)CD25(-)CD44+ fetal thymocytes retained the activity to specifically re-enter the thymus. The attraction was predominantly due to I-A-expressing thymic epithelial cells and was mediated by pertussis toxin-sensitive G-protein signals. Among the chemokines produced by the fetal thymus, CCL21, CCL25, and CXCL12 could attract CD4(-)CD8(-)CD25(-)CD44+ fetal thymocytes. However, fetal thymus colonization was markedly diminished by neutralizing antibodies specific for CCL21 and CCL25, but not affected by anti-CXCL12 antibody. Fetal thymus colonization was partially defective in CCL21-deficient plt/plt mice and was further diminished by anti-CCL25 antibody. These results indicate that CCL21 is involved in the recruitment of T-cell precursors to the fetal thymus and suggest that the combination of CCL21 and CCL25 pl...Continue Reading

References

May 1, 1989·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·I KhazaalN Le Douarin
Oct 1, 1967·The Journal of Experimental Medicine·M A Moore, J J Owen
Jan 1, 1997·European Journal of Immunology·H NakanoA Matsuzawa
Apr 18, 1998·The Journal of Biological Chemistry·R YoshidaO Yoshie
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M NormentM J Bevan
Nov 28, 2000·European Journal of Immunology·C C Bleul, T Boehm
Jan 17, 2002·Journal of Immunological Methods·D H D GrayR L Boyd
Mar 22, 2002·Nature Reviews. Immunology·G Anderson, E J Jenkinson
Dec 3, 2002·FEBS Letters·Tatsuya SaitohShoji Yamaoka
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wolfgang WeningerUlrich H von Andrian
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiaki AraTakashi Nagasawa
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason PlotkinHoward T Petrie
Sep 14, 2004·Methods in Molecular Biology·Tomoo UenoYousuke Takahama

❮ Previous
Next ❯

Citations

Mar 16, 2005·Current Opinion in Immunology·Daniel H D GrayRichard L Boyd
Dec 8, 2010·Immunology and Cell Biology·Mark D BuntingShaun R McColl
Mar 22, 2006·Nature Immunology·Ena LadiEllen A Robey
Feb 24, 2006·Nature Reviews. Immunology·Avinash Bhandoola, Arivazhagan Sambandam
Feb 24, 2006·Nature Reviews. Immunology·Yousuke Takahama
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
Apr 2, 2008·Nature Reviews. Immunology·Reinhold FörsterAntal Rot
Jun 28, 2011·Nature Reviews. Immunology·Paul E Love, Avinash Bhandoola
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lesly Calderón, Thomas Boehm
Jul 13, 2007·International Immunology·Manami ItoiTakashi Amagai
Mar 3, 2010·Infection and Immunity·Shahani NoorEmma H Wilson
Feb 13, 2007·Annual Review of Immunology·Howard T Petrie, Juan Carlos Zúñiga-Pflücker
Mar 3, 2010·American Journal of Respiratory and Critical Care Medicine·Silvia NausHermann J Ziltener
Apr 27, 2012·Journal of Neuroinflammation·Shahani Noor, Emma H Wilson
Aug 25, 2011·Development·Julie Gordon, Nancy R Manley
Dec 26, 2008·Haematologica·Muzlifah A HaniffaFrancesco Dazzi
Apr 5, 2012·Clinical & Developmental Immunology·Rosa RomanoClaudio Pignata
Apr 1, 2014·Cellular and Molecular Life Sciences : CMLS·Joanna HalkiasEllen A Robey
Oct 18, 2008·Seminars in Immunopathology·Daniel A ZlotoffAvinash Bhandoola
Jan 18, 2014·International Reviews of Immunology·Loredana PalamaroClaudio Pignata
Oct 23, 2012·International Reviews of Immunology·Donatella CapalboClaudio Pignata
Sep 1, 2006·Expert Review of Clinical Immunology·Marcus Svensson, William W Agace
Apr 21, 2010·Autoimmunity·Rozen Le PanseSonia Berrih-Aknin
Jan 29, 2013·Progress in Histochemistry and Cytochemistry·Novica M Milićević, Živana Milićević
Jul 31, 2012·Developmental and Comparative Immunology·I-Na LuBei-En Chang
Jul 16, 2010·Seminars in Immunology·Dil Afroz SultanaAvinash Bhandoola
Jun 17, 2008·Progress in Histochemistry and Cytochemistry·Rita RezzaniLuigi Fabrizio Rodella
Feb 7, 2014·European Journal of Immunology·Annika ReinhardtImmo Prinz
Aug 20, 2005·Immunology·Jens V Stein, César Nombela-Arrieta
Oct 23, 2009·Annals of Neurology·Sonia Berrih-AkninRozen Le Panse
Sep 4, 2009·European Journal of Immunology·Yu LeiYousuke Takahama
Aug 19, 2007·European Journal of Immunology·Simona W RossiGraham Anderson
Jun 21, 2007·European Journal of Immunology·William E JenkinsonGraham Anderson
Feb 2, 2006·Immunological Reviews·Georg HolländerYousuke Takahama
Feb 2, 2006·Immunological Reviews·Marie-Eve BlaisClaude Perreault
Feb 2, 2006·Immunological Reviews·Benjamin A Schwarz, Avinash Bhandoola
Feb 2, 2006·Immunological Reviews·Graham AndersonEric J Jenkinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.