The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis

European Journal of Pharmacology
Maureen N AjueborCory M Hogaboam

Abstract

CCL3/macrophage inflammatory protein (MIP-1)-1alpha is elevated in the rectal biopsies of patients with active inflammatory bowel diseases, but its role remains undefined. The present study examined the role of CCL3/MIP-1alpha during trinitrobenzene sulfonic acid (TNBS)-induced colitis in the rat. Colonic CCL3/MIP-1alpha levels were elevated (>20-fold above control) within 24 h and remained elevated to day 7 of colitis induction by TNBS administration. In addition, significant increases in colonic neutrophil accumulation were observed within 24 h to day 7 of TNBS treatment. Pre-treatment of rats with a single dose of CCL3/MIP-1alpha antibody significantly reduced (47%) colonic neutrophil accumulation during the early (24 h) phase of TNBS-induced colitis. In contrast, chronic (repeated) administration of CCL3/MIP-1alpha antibody did not attenuate colonic neutrophil accumulation during the late phase (day 7) of TNBS-induced colitis. These results suggest a role for CCL3/MIP-1alpha in promoting colonic neutrophil accumulation during the early (24 h) phase of TNBS-induced colitis.

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Jan 24, 2004·Experimental and Molecular Pathology·Maureen N AjueborCory M Hogaboam

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Citations

Aug 29, 2009·Inflammatory Bowel Diseases·Pieter P E van LieropEdward E S Nieuwenhuis
Sep 3, 2008·International Journal of Colorectal Disease·Keshen LiDongwei Mao
Jun 27, 2013·PloS One·Daniel HeinrichsHacer Sahin
Dec 10, 2015·Scientific Reports·Juneyoung LeeHiroshi Kiyono
Nov 7, 2009·The American Journal of Pathology·Angélica T VieiraMauro M Teixeira
Jul 15, 2015·Cellular & Molecular Immunology·Darshana PoddarBarsanjit Mazumder
Jun 21, 2015·Genomics, Proteomics & Bioinformatics·Shannon N TessierKenneth B Storey
Jan 19, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jean-Eric GhiaStephen Collins
Aug 15, 2019·PLoS Neglected Tropical Diseases·Rosangela Salerno-GoncalvesMarcelo B Sztein
Nov 9, 2017·Current Protocols in Toxicology·Lucio G Costa
Aug 22, 2008·The Journal of Pharmacology and Experimental Therapeutics·Sakae MikamiTsutomu Chiba
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chi-Hsun HsiehIrshad H Chaudry
Apr 15, 2011·Clinical and Experimental Immunology·S-H HeP-C Yang

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