PMID: 8598282Jan 1, 1996Paper

The role of CcpA transcriptional regulator in carbon metabolism in Bacillus subtilis

FEMS Microbiology Letters
T M Henkin

Abstract

The CcpA protein has been identified as a key regulator of carbon metabolism in Bacillus subtilis. CcpA is a DNA binding protein in the LacI/GalR transcriptional repressor family, and genes which respond to CcpA contain common cis-acting target sequences (Ccp boxes). A number of pathways involved in carbon source utilization are repressed by CcpA, while at least one gene which is involved in excretion of excess carbon is activated by CcpA. Genes repressed by CcpA generally contain Ccp boxes within or downstream of the promoter, while ackA, which is activated by CcpA, contains Ccp boxes upstream of the promoter. It therefore appears that CcpA acts globally to direct carbon flow in B. subtilis.

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Citations

Apr 3, 2003·FEMS Microbiology Letters·Jessica B Warner, Juke S Lolkema
May 14, 1999·Current Opinion in Microbiology·J Stülke, W Hillen
Apr 19, 2002·Nature·Russell F Doolittle
May 3, 2002·Molecular Microbiology·Hyun-Jin KimAbraham L Sonenshein
Jan 28, 2012·Acta Crystallographica. Section D, Biological Crystallography·Kateřina ProcházkováPavlína Rezáčová
Jun 27, 2001·Applied and Environmental Microbiology·L MuscarielloM Sacco
Oct 6, 2005·Applied and Environmental Microbiology·Tamara Aleksandrzak-PiekarczykJacek Bardowski
May 27, 2008·Journal of Bacteriology·Biju JosephWerner Goebel
Jun 12, 2013·Journal of Bacteriology·Brendaliz SantiagoRobert G Quivey
Jul 1, 2008·Journal of Bacteriology·Simon TännlerStéphane Aymerich
Jan 29, 2008·Journal of Bacteriology·Jacqueline AbranchesRobert A Burne
Oct 24, 2007·Journal of Bacteriology·Marcelle M NascimentoRobert A Burne
Feb 9, 2010·Journal of Bacteriology·Tianqi Sun, Josef Altenbuchner
Jan 12, 2000·Journal of Bacteriology·C M GibsonM G Caparon
Mar 14, 2000·Journal of Bacteriology·P L HuynhR Brückner
Mar 29, 2001·Journal of Bacteriology·N O AliM Debarbouille
May 20, 2004·Journal of Bacteriology·Boris R BelitskyAbraham L Sonenshein
Apr 20, 2004·Journal of Bacteriology·Robert GerstmeirBernhard J Eikmanns
Nov 4, 2005·Journal of Bacteriology·Graciela L LorcaMilton H Saier
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Robert A Bender
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Jessica B Warner, Juke S Lolkema
Mar 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Alan J Wolfe
Nov 28, 2012·Biotechnology for Biofuels·Vasiliki TsakraklidesChristopher D Herring
May 7, 2004·Genome Biology·Richard J S BaerendsOscar P Kuipers

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