PMID: 8603998Feb 1, 1996Paper

The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue

Journal of Leukocyte Biology
W E RoteM Moyle

Abstract

The CD11/CD18 leukocyte integrins are necessary for tissue localization of neutrophils, an early requisite event in inflammation. We have analyzed the contribution of CD11a/CD18 and CD11b/CD18 to local neutrophil accumulation and tissue injury in the reverse passive Arthus reaction in the rat dermis. Experimental groups comprised animals that received an intravenous infusion of (1) recombinant neutrophil inhibitory factor (NIF), a hookworm-derived antagonist of CD11b/CD18; (2) monoclonal antibody to CD11a/CD18 (TA-3); (3) a combination of these agents; (4) a monoclonal antibody to CD18 (WT.3); or (5) saline. Administration of recombinant NIF or anti-CD11a/CD18 monoclonal antibody alone produced a slight reduction in neutrophil accumulation but did not affect edema formation. In contrast, a combination of these antagonists yielded a significant reduction in neutrophil accumulation and a modest reduction in edema, equivalent to levels observed with either anti-CD18 antibodies or animals that were rendered neutropenic. These results indicate that neutrophil infiltration in rat dermal tissue in the reverse passive Arthus reaction is dependent predominantly on the leukocyte integrins CD11a/CD18 and CD11b/CD18 and that either of thes...Continue Reading

Citations

Aug 1, 1997·Basic Research in Cardiology·R J GuminaG J Gross
Jul 2, 1998·Clinical and Experimental Immunology·L L SantosS R Holdsworth
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuko KaburagiShinichi Sato
Mar 28, 2013·Journal of Leukocyte Biology·Friederike JönssonPierre Bruhns
Mar 17, 2020·Parasites & Vectors·Asmaa M I AbuzeidGuoqing Li
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Kazuhiro MinegishiYasunori Yoshimura
Oct 26, 2012·Journal of Anesthesia·Carla CarboMotomu Shimaoka
Oct 5, 2020·Parasite Immunology·Luisa Mourão Dias MagalhãesLilian Lacerda Bueno
Jun 23, 1999·The American Journal of Medicine·C G Kevil, D C Bullard

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