The role of CD4+ T cells in the induction of contact hypersensitivity to mercury in a murine model

Cutaneous and Ocular Toxicology
Yustina A A SumiwiWihaskoro Sosroseno

Abstract

The exact immunopathogenesis of contact hypersensitivity (CH) to mercury remains unclear. The aim of the present study was to assess the role of CD4+ T cells in mercury-induced CH in mice. Splenic CD4+ T cells obtained from nonsensitized and mercury-sensitized Balb/c mice were adoptively transferred to groups I and II of the syngeneic recipients, respectively. All recipients were ear-challenged with mercury. The next experiments were to transfer nonsensitized CD4+ T cells to group A of the recipients, whereas mercury-sensitized CD4+ T cells were transferred to groups B and C. Groups A and B were ear-challenged with mercury, whereas group C was ear-challenged with chromium. The ear swelling 24 hours and 48 hours after challenge was used to assess CH. The results of the present study showed that mercury-sensitized but not nonsensitized CD4+ T cells could transfer CH in mice. Furthermore, mercury-sensitized CD4+ T cells could transfer the induction of CH only in the recipients that were challenged with mercury, but not those that were challenged with chromium. The results of the present study suggest that mercury-induced CH may be mediated by mercury-specific CD4+ T cells.

References

Jan 1, 1991·International Archives of Allergy and Applied Immunology·K J VreeburgR J Scheper
Feb 27, 1999·Contact Dermatitis·L KanervaR Jolanki
Jun 26, 2001·Contact Dermatitis·J Y LeeH O Kim
Apr 22, 2006·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Apr 2, 2008·International Journal of Dermatology·Yetunde M OlumideNyomudim Essen
May 8, 2008·Current Directions in Autoimmunity·Michael D Gober, Anthony A Gaspari
Oct 14, 2008·British Dental Journal·V K BainsR Bains

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Citations

Jun 11, 2020·International Journal of Molecular Sciences·Hiroaki ShigematsuRyuji Suzuki

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