The role of CD40-CD40 ligand interactions in suppression of human B cell responsiveness by CD4+ T cells

Cellular Immunology
S Hirohata

Abstract

Although human T cells have been shown to regulate humoral immune responses by directly inhibiting B cells, the precise sequelae for the mechanism of suppression have not yet been delineated. The present study was therefore examined to explore the nature of T cell-B cell collaboration to suppress B cell responses. Special attention was directed to the roles of Fas (CD95)-Fas ligand (FasL) interactions and CD40-CD40 ligand (CD40L) interactions. The suppressive activity was assessed by the effects of mitomycin C untreated CD4+ T cells (control CD4+ T cells) activated by immobilized anti-CD3 for 72 h on the production of IgM and IgG of B cells stimulated for 72 h with immobilized anti-CD3-activated mitomycin C treated CD4+ T cells. In this model system, B cells stimulated with anti-CD3-activated CD4+ T cells have been shown to express functional Fas receptor. Thus, anti-Fas mAb CH11 inhibited the production of IgM and IgG induced by anti-CD3-activated mitomycin C treated CD4+ T cells in a manner that was completely reversed by a neutralizing anti-Fas mAb ZB4. However, neither ZB4 nor anti-FasL mAb reversed the suppression of B cell responses by anti-CD3-activated control CD4+ T cells. Anti-CD40L mAb inhibited the production of IgM...Continue Reading

References

Oct 17, 1991·Nature·J Banchereau, F Rousset
Mar 10, 1995·Science·S Nagata, P Golstein
Feb 11, 1993·Nature·J P DiSantoG de Saint Basile

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Citations

Feb 5, 1999·Clinical and Experimental Immunology·S Hirohata
Mar 20, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuharu Ohshima, Shunsei Hirohata
Apr 11, 2019·Nature Reviews. Rheumatology·Samuel J S RubinWilliam H Robinson
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·M R O'GormanR Yogev
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jesús Martínez-BarnetcheJosé Moreno

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