PMID: 16505601Mar 1, 2006Paper

The role of CD4+CD25+ regulatory T cells in patients with Rheumatoid Arthritis

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Rumi MinamiEiichi Suematsu

Abstract

CD4(+)CD25(+) regulatory T cells play an important role in preventing autoimmunity. We investigated the presence of CD4(+)CD25(+) regulatory T cells in the peripheral blood of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), using flow cytometry. The percentage of CD4(+)CD25(+) regulatory T cells was significantly decreased in RA, especially in patients with high serum levels of either CRP or MMP-3. In SSc and SLE, the percentage of CD4(+)CD25(+) regulatory T cells was higher in patients than in controls, but not significant. We also investigated the serum levels of IL-10, which influences the function of CD4(+)CD25(+) regulatory T cells and other regulatory T cells. In RA, on contrast to CD4(+)CD25(+) regulatory T cells, the serum levels of IL-10 increased in patients with higher serum levels of CRP, or MMP-3. In SLE and SSc, the serum level of IL-10 increased significantly in patients than in controls. These data thus indicated that CD4(+)CD25(+) regulatory T cells contributes to occurrence and progression of RA, and other regulatory T cells or cytokines contribute to occurrence and progression of SSc and SLE.

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Citations

May 28, 2014·Clinical Rheumatology·Azza A EltayebTahra M Sheref
Feb 27, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·N A AzabM A Mashahit

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