The role of CD8+ cells in the establishment and maintenance of a Trichuris muris infection

Parasite Immunology
Neil E HumphreysRichard K Grencis

Abstract

Chronic infection by the caecal-dwelling intestinal murine nematode Trichuris muris occurs if given as a high-dose infection to 'susceptible' AKR mice or as a low-dose infection to the normally 'resistant' C57BL/6 mouse strain. Both regimes result in a type 1 cytokine response, i.e. high levels of IFN-gamma and IL-12. Here we show this susceptible response is associated with a large population of CD8(+) IFN-gamma(+) cells within the mesenteric lymph nodes and numerous CD8(+) cells infiltrating the caecal mucosa. Despite this, the in vivo abolition of CD8(+) cells within AKR and C57BL/6 mice, either prior to infection or once infection has become established, failed to affect chronicity, implying that CD8(+) T cells are not essential for the initiation or maintenance of the susceptible response to T. muris. Interestingly, the percentage of IFN-gamma(+) CD4(+) cells increased in treated groups, perhaps in a compensatory role. The majority of antigen-specific cytokine responses were comparable in both treated and control groups, although IL-5 was fivefold higher in animals receiving anti-CD8 mAbs and IFN-gamma was also raised in treated mice. Mastocytosis was unaltered by CD8 depletion, however, paradoxically, eosinophilia within ...Continue Reading

References

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Citations

Oct 12, 2012·Seminars in Immunopathology·Joanna E KlementowiczRichard K Grencis
Jul 31, 2014·PloS One·Oscar Flórez-VargasAndy Brass
Jan 1, 2013·ISRN Parasitology·Priscila Guirão LaraMara Silvia Carvalhaes

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