The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation

Human Immunology
Alla L Zozulya, Heinz Wiendl

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune diseases. MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have long been regarded as a CD4(+) T-cell-mediated autoimmune disease. Studies addressing the role of CD8(+) T cells, however, have only recently begun to emerge. Pathogenic function was attributed to CD8(+) T cells because of their abundant presence or oligoclonal repertoire within MS lesions. However, CD8(+) T cells appeared to have important regulatory functions, as demonstrated in EAE or human MS studies. We here review the contribution of CD8(+) T cells to inflammation and immune regulation in CNS autoimmunity. The knowledge of distinct CD8(+) T-cell populations exerting destructive versus beneficial functions is summarized. The long-term goal is to delineate the exact phenotypic and functional characteristics of regulatory CD8(+) T-cell populations (natural as well as inducible) in humans. This knowledge may help to further develo...Continue Reading

References

Aug 1, 1986·The Journal of Clinical Investigation·M B BaniaB G Arnason
Apr 1, 1984·Journal of Neuroimmunology·H L WeinerS L Hauser
Aug 1, 1994·Annals of Neurology·J W LindseyL Steinman
Aug 26, 1998·The Journal of Experimental Medicine·J D WilsonA J McMichael
Nov 7, 1999·Journal of Autoimmunity·S Pouly, J P Antel
May 29, 2000·Brain : a Journal of Neurology·A BitschW Brück
Jun 16, 2000·Journal of Neuroimmunology·J CorrealeL P Weiner
Sep 6, 2001·The Journal of Experimental Medicine·E S HusebyJ Goverman
Sep 11, 2001·The American Journal of Pathology·I MedanaH Neumann
Mar 2, 2002·Brain : a Journal of Neurology·Marc JacobsenBernhard Hemmer
Mar 20, 2002·The Journal of Experimental Medicine·Michel Gilliet, Yong-Jun Liu
Jun 28, 2002·Trends in Neurosciences·Harald NeumannHans Lassmann
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christian SkulinaNorbert Goebels
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
Apr 21, 2004·Nature Immunology·Dan HuHarvey Cantor
Nov 3, 2004·The Journal of Experimental Medicine·Muhaimin Rifa'iHaruhiko Suzuki
Dec 14, 2004·International Immunopharmacology·Nicole Suciu-FocaRaffaello Cortesini
Jan 22, 2005·Neurologic Clinics·Amit Bar-Or
Jun 25, 2005·Brain : a Journal of Neurology·Manuel A Friese, Lars Fugger
Sep 24, 2005·European Journal of Immunology·Lorna B JarvisJ S Hill Gaston
Jan 19, 2006·Clinical Microbiology Reviews·Robert S FujinamiJ Lindsay Whitton
Mar 23, 2007·Annals of the New York Academy of Sciences·Qingyong Ji, Joan Goverman
Sep 25, 2007·Brain : a Journal of Neurology·Andreas JunkerKlaus Dornmair
Feb 1, 2008·Journal of Neuroimmunology·Jorge Correale, Andrés Villa
Jun 26, 2008·Nature Clinical Practice. Neurology·Alla L Zozulya, Heinz Wiendl

❮ Previous
Next ❯

Citations

May 28, 2013·Trends in Immunology·Sarah B SimmonsJoan M Goverman
May 16, 2009·Nature Reviews. Immunology·Joan Goverman
Dec 19, 2013·Journal of Neuroinflammation·Mahdia BenkhouchaPatrice H Lalive
Mar 30, 2013·The International Journal of Biochemistry & Cell Biology·Romy RazakandrainibeRonan Jambou
May 15, 2013·Journal of Neuroimmunology·Monika CamaraThomas Kerkau
Apr 18, 2014·Drugs·Amit Bar-OrHeinz Wiendl
Sep 23, 2014·Iranian Red Crescent Medical Journal·Abbas Ebrahimi KalanAmaneh Mohammadi Roushandeh
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Tom L Van BelleChantal Mathieu
Jun 19, 2010·Progress in Neurobiology·Eilhard MixUwe K Zettl
Feb 23, 2010·Journal of Autoimmunity·Nathan R YorkNitin J Karandikar
Dec 8, 2009·Experimental Neurology·Josephine HerzVolker Siffrin
Sep 29, 2009·Trends in Immunology·Helgi ValdimarssonAndrew Johnston
Jun 29, 2010·Annals of Neurology·Stefan BittnerSven G Meuth
Jul 20, 2010·Biochimica Et Biophysica Acta·Lennart T MarsNathalie Arbour
Nov 28, 2012·Journal of Neuroimmunology·Laya KafamiAhmadreza Dehpour
Jul 6, 2016·Frontiers in Cellular Neuroscience·André L BombeiroAlexandre L R Oliveira
Jun 17, 2016·Inflammatory Bowel Diseases·Michael R TomSubrata Ghosh
Jul 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nico MelzerHeinz Wiendl
Jan 6, 2018·Journal of Neuropathology and Experimental Neurology·Rana A EserLea T Grinberg
Jun 14, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander W BoydenNitin J Karandikar
Apr 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah Y Lee, Joan M Goverman
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe SaikaliNathalie Arbour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.