The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review

Cancer Cell International
Kai LiuShiwu Zhang

Abstract

One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasive, metastatic, drug-resistance, and anti-apoptotic abilities. Recently, an increasing number of cell cycle-associated proteins have become the candidate biomarkers for early diagnosis of malignant tumors and potential targets for cancer therapies. As an important cell cycle regulatory protein, Cell Division Cycle 25C (CDC25C) participates in regulating G2/M progression and in mediating DNA damage repair. CDC25C is a cyclin of the specific phosphatase family that activates the cyclin B1/CDK1 complex in cells for entering mitosis and regulates G2/M progression and plays an important role in checkpoint protein regulation in case of DNA damage, which can ensure accurate DNA information transmission to the daughter cells. The regulation of CDC25C in the cell cycle is affected by multiple signaling pathways, such as cyclin B1/CDK1, PLK1/Aurora A, ATR/CHK1, ATM/CHK2, CHK2/ERK, Wee1/Myt1, p53/Pin1, and ASK1/JNK-/38. Recently, it has evident that changes in the expression of CDC25C are closely related to tumorigenesis and tumor dev...Continue Reading

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Citations

Oct 29, 2020·Technology in Cancer Research & Treatment·Ruifeng XunXianwang Wang
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Eriko Ohsaki, Keiji Ueda
Apr 4, 2021·Cancers·Nguyen Thi Thanh HoKlaus Heese
Apr 15, 2021·The Journal of Cell Biology·Alexandre T VessoniLuis F Z Batista
Apr 30, 2021·Environmental Toxicology·Rodrigo Aníbal Mateos-NavaMario Agustín Altamirano-Lozano
Aug 8, 2021·Cancers·Paing LinnChiaki Takahashi
Sep 30, 2021·American Journal of Physiology. Cell Physiology·Sukanya SrivastavaGeetha Suryakumar

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Methods Mentioned

BETA
ubiquitination
X-ray
nuclear translocation
complete nuclear translocation
two-hybrid
biopsy

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