The role of Cdc42 in signal transduction and mating of the budding yeast Saccharomyces cerevisiae.

The Journal of Biological Chemistry
L J Oehlen, F R Cross

Abstract

The small G-protein Cdc42 functions in many eukaryotic signal transduction pathways. In the budding yeast Saccharomyces cerevisiae, cells with defective Cdc42 fail to induce mating-specific genes in response to mating factor and to adopt the proper morphology for conjugation. Here we show that the failure of mating factor-induced transcription is largely the indirect result of arrest at a specific cell cycle position and/or the accumulation of high levels of the Cln1/2-Cdc28 kinase, a known repressor of mating factor signal transduction. Cdc42-defective cells with restored transcriptional induction have a partially restored mating ability but are still defective in the morphological response to mating factor. These results show that Cdc42 is not required for transduction of the mating factor signal per se but that it is essential for proper mating factor-induced morphogenesis.

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Citations

Mar 22, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K HirotaM Yamamoto
Jul 9, 2002·Molecular Microbiology·Gerhard WeinzierlMichael Bölker
Mar 31, 2006·Molecular Biology of the Cell·Sophie BaraleRobert A Arkowitz
Dec 26, 2006·Eukaryotic Cell·Melanie HeinrichHans-Ulrich Mösch
Sep 26, 2000·Molecular and Cellular Biology·J J MoskowD J Lew
Apr 10, 2002·Molecular and Cellular Biology·Rachel E LamsonPeter M Pryciak
Jun 8, 2001·Annual Review of Biochemistry·H G Dohlman, J W Thorner
Sep 17, 1998·The Journal of Biological Chemistry·L J Oehlen, F R Cross
Aug 11, 2019·The Journal of Biological Chemistry·Nambirajan RangarajanHenrik G Dohlman
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·D I Johnson

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