The role of CELF proteins in neurological disorders.

RNA Biology
Jean-Marc Gallo, Carl Spickett

Abstract

CELF (CUG-BP and ETR-3-like factors) proteins are structurally related RNA-binding proteins involved in various aspects of RNA processing including splicing and mRNA stability. The first member of the family, CELF1/CUG-BP1, was identified through its role in myotonic dystrophy, type 1. Several recent studies have uncovered the recurrent implication, to various extents, of CELF proteins or of the functionally related muscleblind-like 1 protein in a number of neurological conditions. This is particularly clear for inherited neurodegenerative disorders caused by expansions of translated or untranslated triplet repeats in the causative gene. Here we review the role played by CELF proteins, at least as modifiers of the pathological phenotype, in a number of neurological diseases. The involvement of CELF proteins suggest that individual pathogenic pathways in a number of neurological conditions overlap at the level of RNA processing.

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Citations

Feb 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Ting-Yu LinChing-Wei Luo
Oct 27, 2015·Journal of Cellular Physiology·Hany MareiThomas Caceci
Jan 13, 2018·Molecular Medicine Reports·Fei ZouZheng-Rong Sun
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Jul 24, 2012·Biochemical Society Transactions·Michael Niblock, Jean-Marc Gallo
Dec 9, 2015·Genes, Brain, and Behavior·Camron D Bryant, Neema Yazdani
Apr 6, 2021·Frontiers in Aging Neuroscience·David VogrincVita Dolžan
Jun 3, 2021·International Journal of Molecular Sciences·Chisato KinoshitaKoji Aoyama
May 31, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jixing ZhongDongsheng Chen

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