The role of cell cycle in retinal development: cyclin-dependent kinase inhibitors co-ordinate cell-cycle inhibition, cell-fate determination and differentiation in the developing retina

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Aikaterini Bilitou, Shin-ichi Ohnuma

Abstract

The mature retina is formed through multi-step developmental processes, including eye field specification, optic vesicle evagination, and cell-fate determination. Co-ordination of these developmental events with cell-proliferative activity is essential to achieve formation of proper retinal structure and function. In particular, the molecular and cellular dynamics of the final cell cycle significantly influence the identity that a cell acquires, since cell fate is largely determined at the final cell cycle for the production of postmitotic cells. This review summarizes our current understanding of the cellular mechanisms that underlie the co-ordination of cell-cycle and cell-fate determination, and also describes a molecular role of cyclin-dependent kinase inhibitors (CDKIs) as co-ordinators of cell-cycle arrest, cell-fate determination and differentiation.

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Citations

May 13, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Mathieu Boissan, Marie-Lise Lacombe
Apr 25, 2012·Development, Growth & Differentiation·Margaret DellettShin-ichi Ohnuma
Jul 16, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Minde I Willardsen, Brian A Link
Jun 12, 2013·Developmental Biology·Marie A Forbes-OsborneAnn C Morris
Feb 22, 2011·Developmental Biology·Reyna I Martinez-De LunaHeithem M El-Hodiri
Dec 30, 2014·Cellular and Molecular Life Sciences : CMLS·Krisztina Takács-VellaiAnil Mehta
Jun 5, 2012·Developmental Biology·Sarah A HutchinsonNikolaus S Trede
Aug 26, 2016·Molecular Neurobiology·Luana de Almeida-PereiraLucianne Fragel-Madeira
Aug 22, 2006·Trends in Neurosciences·Michel CayouetteWilliam A Harris

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