The role of cellular adhesion molecules in surgery

The Australian and New Zealand Journal of Surgery
A F BreidahlW A Morrison

Abstract

The purpose of this review is to detail the roles played by the cellular adhesion molecules (CAM) in inflammatory and immunological reactions relevant to surgery. The interactions between leucocytes and endothelial cells which are mediated by CAM are central to the development of ischaemia/reperfusion injury (IRI) as occurs when blood flow is restored after an ischaemic period; for example, following revascularization of replanted digits and microvascular tissue transfers, angioplasty and tourniquet procedures. Cellular adhesion molecules are also important in wound healing and other inflammatory processes. In addition, the immunological response to organ allograft transplantation is mediated by cellular interactions mediated by CAM. This review details the functions and regulation of the various CAM involved in inflammation and allograft rejection and summarizes the results of previous surgical studies in which various techniques have been used to block the interactions mediated by CAM in an attempt to improve surgical outcomes.

References

Oct 1, 1992·The American Journal of Physiology·N FarmanJ P Bonvalet
Aug 1, 1991·European Heart Journal·M RoseM Yacoub
May 1, 1991·Australian and New Zealand Journal of Ophthalmology·R H Guymer, T E Mandel
Sep 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·W MoolenaarF J van der Woude
Aug 2, 1990·Nature·T A Springer
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Jan 1, 1986·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A SpringerD C Anderson
Feb 1, 1994·Current Opinion in Immunology·R P McEver
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Oct 1, 1993·The Journal of Clinical Investigation·R K WinnJ M Harlan
Aug 1, 1993·Molecular Biology of the Cell·M SubramaniamD D Wagner
Jun 1, 1994·Plastic and Reconstructive Surgery·L P BuckyJ W May
Jan 1, 1994·Annals of Surgery·U W HeemannN L Tilney
Aug 1, 1993·The Journal of Experimental Medicine·W A MullerD M Phillips

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Citations

Oct 11, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus H C RichterHans Georg Olbrich
Jan 30, 2014·Perioperative Medicine·Daniela C IonescuDaniel I Sessler

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