The Role of Central and Enteric Nervous Systems in the Control of the Retrograde Giant Contraction

Journal of Neurogastroenterology and Motility
I M Lang


The role of the enteric (ENS) and central (CNS) nervous systems in the control of the retrograde giant contraction (RGC) associated with vomiting is unknown. The effects of myotomy or mesenteric nerve transection (MNT) on apomorphine-induced emesis were investigated in 18 chronically instrumented dogs. Neither surgery affected the RGC orad of the surgical site or the velocity of the RGC over the entire small intestine. Myotomy blocked the RGC for 17 ± 5 cm aborad of the myotomy, and the velocity of the RGC from 100 to 70 cm from the pylorus slowed (18.1 ± 3.0 to 9.0 ± 0.8 cm/sec) such that the RGC orad and aborad of the myotomy occurred simultaneously. After MNT, the RGC was unchanged up to 66 ± 6 cm from the pylorus, and the sequence of the RGC across the denervated intestine was unaltered. The velocity of the RGC from 100 to 70 cm from the pylorus increased from 12.8 ± 1.6 to 196 ± 116 cm/sec. After myotomy or MNT, the percent occurrence and magnitude of the RGC across the intestine 100 to 70 cm from the pylorus decreased. The CNS activates the RGC 10 to 20 cm aborad of its innervation of the intestine and controls the RGC sequence. On the other hand, the ENS plays a role in initiation and generation of the RGC.


Sep 1, 1991·Journal of the Autonomic Nervous System·A J MacGilchristG A Rick
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Mar 1, 1987·Gastroenterology·C T FrantzidesR E Condon
Feb 1, 1988·The American Journal of Physiology·I M LangS K Sarna
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Nov 1, 1993·The American Journal of Physiology·I M LangW J Dodds
Feb 1, 1993·Journal of the Autonomic Nervous System·H R Berthoud, T L Powley
Jun 28, 2000·Journal of the Autonomic Nervous System·J B Furness
Jan 9, 2001·The Anatomical Record·S J Brookes
Jul 15, 1946·The Journal of Physiology·R A Gregory
Sep 1, 1949·Journal of Neurophysiology·H L BORISON, S C WANG
Jun 21, 2014·Journal of Neurogastroenterology and Motility·Peter J BlairSean M Ward
Mar 6, 2015·Journal of Visualized Experiments : JoVE·David E Fried, Brian D Gulbransen

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Sep 21, 2018·Frontiers in Pharmacology·Gareth J Sanger, Paul L R Andrews

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