The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain.

Pain
A FoxI James

Abstract

We have examined the effects of cannabinoid agonists on hyperalgesia in a model of neuropathic pain in the rat and investigated the possible sites of action. The antihyperalgesic activity of the cannabinoids was compared with their ability to elicit behavioural effects characteristic of central cannabinoid activity. WIN55,212-2 (0.3-10 mg kg(-1)), CP-55,940 (0.03-1 mg kg(-1)) and HU-210 (0.001-0.03 mg kg(-1)) were all active in a 'tetrad' of tests consisting of tail-flick, catalepsy, rotarod and hypothermia following subcutaneous administration, with a rank order of potency in each of HU-210 > CP-55,940 > WIN55,212-2. The effects of WIN55,212-2 in each assay were blocked by the Cannabinoid1 (CB1) antagonist SR141716A. In the partial sciatic ligation model of neuropathic pain WIN55,212-2, CP-55,940 and HU-210 produced complete reversal of mechanical hyperalgesia within 3 h of subcutaneous administration with D50 values of 0.52, 0.08 and 0.005 mg kg(-1), respectively. In this model WIN55,212-2 was also effective against thermal hyperalgesia and mechanical allodynia. WIN55,212-2 produced pronounced reversal of mechanical hyperalgesia following intrathecal administration that was blocked by the CB1 antagonist SR141716A. Following i...Continue Reading

References

Feb 8, 1980·European Journal of Pharmacology·D E Moss, R L Johnson
Dec 1, 1994·Journal of Pharmacological and Toxicological Methods·C MestreA Eschalier
Feb 9, 1993·European Journal of Pharmacology·E Fride, R Mechoulam
May 1, 1997·Pharmacology, Biochemistry, and Behavior·A H Lichtman, B R Martin
Apr 16, 1998·Pain·Jennelle Durnett RichardsonKenneth M Hargreaves
May 26, 1998·European Journal of Pharmacology·J D RichardsonK M Hargreaves
Jul 31, 1998·Nature·A CalignanoD Piomelli
Jul 30, 1999·Neuroscience·A G Hohmann, M Herkenham
May 10, 2000·Critical Reviews in Neurobiology·F Chaperon, M H Thiébot
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·M Costigan, C J Woolf

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Citations

Jan 20, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Anna LeichsenringHermann Lübbert
Aug 4, 2004·Psychopharmacology·P Alexander Arguello, J David Jentsch
Mar 21, 2007·Bulletin of Experimental Biology and Medicine·M L KukushkinN V Gretskaya
Apr 25, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Bo ShiLinghua Liu
Aug 12, 2006·Current Treatment Options in Neurology·Raphael J Leo
Jan 7, 2004·Life Sciences·Diana L Cichewicz
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elizabeth J Rahn, Andrea G Hohmann
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Christopher J FowlerStig O P Jacobsson
Dec 31, 2002·Chemistry and Physics of Lipids·T Philip MalanFrank Porreca
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Aug 19, 2003·European Journal of Pharmacology·Kayo Morita, Junzo Kamei
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jan 12, 2002·Current Opinion in Pharmacology·Leslie Iversen, Victoria Chapman
Jul 20, 2013·Journal of Medicinal Chemistry·Sangdon HanRobert M Jones
Nov 16, 2005·Behavioural Pharmacology·Jay Paquette, Mary C Olmstead
Sep 21, 2013·The Cancer Journal·Shalini DalalEduardo Bruera
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·Vanessa A MitchellChristopher W Vaughan
Jul 31, 2008·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth J RahnAndrea G Hohmann
Aug 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Andrew J Kwilasz, S Stevens Negus
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Sep 12, 2008·Journal of Neurophysiology·Carl PotenzieriDonald A Simone
Jan 20, 2007·The AAPS Journal·Andrea G Hohmann, Richard L Suplita
Mar 6, 2003·CNS Drugs·J Ludovic Croxford
Dec 15, 2010·Drugs·Matthias KarstJörg Ahrens
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Scott M Rawls, Khalid Benamar
Feb 27, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jun ShenJianguo Cheng

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