The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case-control study

AIDS
Christian FelleyJean-Louis Frossard

Abstract

Pancreatic disorders in HIV-positive patients are frequent. CFTR and SPINK-1 mutations have been reported to increase the risk of pancreatitis, but no data are available in HIV-positive patients. This study will evaluate the frequency of CFTR mutations and SPINK-1 polymorphisms in HIV-positive patients with clinical pancreatitis or asymptomatic elevation of serum pancreatic enzymes. Cases (patients with hyperamylasemia) were identified during a toxicity study conducted in August 1999 among 1152 participants of the Swiss HIV Cohort Study. We designed a case-control study in which each case was matched one to one to an HIV-infected control according to sex, age, CD4 cell count, viraemia and medication use. CFTR mutations and SPINK-1 polymorphisms were studied using polymerase chain reaction techniques. Fifty-one HIV-positive patients with hyperamylasemia were detected among 1152 participants in the toxicity study (4.4%). There were 13 carriers of CFTR and SPINK-1 mutations (12.7%). Amylase levels were 316 +/- 130 U/l for the group with mutations, and 135 +/- 18 U/l for non-carriers (P = 0.79). However, among patients with hyperamylasemia, those with CFTR or SPINK-1 mutations had 648 +/- 216 U/l amylase levels compared with 232 +/...Continue Reading

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Citations

Feb 8, 2006·The Pharmacogenomics Journal·S Rodríguez-NóvoaV Soriano
Dec 2, 2009·International Journal of Epidemiology·UNKNOWN Swiss HIV Cohort StudyPatrick Francioli
Jul 25, 2009·Journal of Tropical Pediatrics·Léon Mutesa, Vincent Bours
Mar 11, 2005·Journal of Clinical Gastroenterology·Jonathan A Cohn
Sep 22, 2007·Annual Review of Pharmacology and Toxicology·A Telenti, U M Zanger
Apr 30, 2008·World Journal of Gastroenterology : WJG·Jean-Louis FrossardAntoine Hadengue
Mar 27, 2009·World Journal of Gastroenterology : WJG·Guo-Jun WangSi-Qin Ding
Oct 22, 2009·Pharmacogenomics·Sonia Rodriguez-NovoaVincent Soriano
Sep 12, 2009·Antiviral Research·Valerio Tozzi
Mar 3, 2009·Medicina clínica·Bernardino Roca
Apr 25, 2006·Endocrinology and Metabolism Clinics of North America·Rodger A Liddle
Jul 2, 2004·Enfermedades infecciosas y microbiología clínica·Amalio Telenti
Dec 6, 2017·Pharmacogenomics·Jessica CusatoAntonio D'Avolio
Jan 15, 2008·Lancet·Jean-Louis FrossardCatherine M Pastor
Dec 17, 2008·Enfermedades infecciosas y microbiología clínica·Victoria Sánchez Hellín, Félix Gutiérrez Rodero

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