The Role of Charge Density and Hydrophobicity on the Biocidal Properties of Self-Protonable Polymeric Materials

Macromolecular Bioscience
Simona MatrellaLorella Izzo

Abstract

Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as a function of the architecture, the N-substituent groups of the AAEMAs (methyl, ethyl, isopropyl, and tert-butyl groups) and the hydrophobic/charge density balance. Antimicrobial effectiveness and efficiency is controlled by the surface charge density and by the influence of N-alkyl groups on the surface morphology. Also interestingly, it is the absence of hemolitytic activity in all copolymers. In presence of Escherichia coli, the A(BC)2 copolymer with 40% of N-methyl groups is the most efficient, killing 91% of the bacteria already after 1.5 h.

References

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Citations

Nov 5, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Andrea TagliabueMassimo Mella
Aug 16, 2017·Journal of Drug Targeting·Simone VillaniLorella Izzo
Apr 10, 2020·Biochimica Et Biophysica Acta. General Subjects·Ylenia MieleFederico Rossi
Mar 20, 2021·ACS Infectious Diseases·Joshua B JonesShonna M McBride
Oct 9, 2017·ACS Biomaterials Science & Engineering·Steven MankociAbraham Joy

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