The role of checkpoints in the treatment of GBM

Journal of Neuro-oncology
Jennifer E Kim, Michael Lim

Abstract

Targeted immunotherapy is founded on the principle that augmentation of effector T cell activity in the tumor microenvironment can translate to tumor regression. Targeted checkpoint inhibitors in the form of agonist or antagonist monoclonal antibodies have come to the fore as a promising strategy to activate systemic immunity and enhance T cell activity by blocking negative signals, enhancing positive signals, or altering the cytokine milieu. This review will examine several immune checkpoints and checkpoint modulators that play a role in cancer pathogenesis, with an emphasis on malignant gliomas.

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Jul 14, 2016·Expert Opinion on Biological Therapy·Neha KamranMaria G Castro
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